Tretinoin

Tretinoin
(IUPAC) ime
	Retinoinska kiselina
Klinički podaci
Robne marke	Avita, Renova, Retin
AHFS/Drugs.com	Monografija
MedlinePlus	a682437
Identifikatori
CAS broj	302-79-4
ATC kod	D10AD01 L01XX14
PubChem	444795
DrugBank	DB00755
ChemSpider	392618
UNII	5688UTC01R
KEGG	D00094
ChEBI	CHEBI:15367
ChEMBL	CHEMBL38
Hemijski podaci
Formula	C20H28O2
Mol. masa	300,4412 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ ; Key: SHGAZHPCJJPHSC-YCNIQYBTSA-N
Fizički podaci
Tačka topljenja	180 °C (356 °F)
Farmakokinetički podaci
Vezivanje za proteine plazme	> 95%
Poluvreme eliminacije	0,5-2 sata
Farmakoinformacioni podaci
Licenca	US Daily Med:link
Trudnoća	?
Pravni status	Samo na recept (S4) (AU) POM (UK) ℞-only (SAD)
Način primene	Topikalno, oralno

Tretinoin je kiselinska forma vitamina A. On je poznat kao sve-trans retinoinska kiselina ili ATRA. Tretinoin je lek koji se koristi za tretiranje acne vulgaris i keratosis pilaris. On je dostupan u obliku krema ili gela (Aberela, Airol, Renova, Atralin, Retin-A, Avita, Retacnyl, Refissa, or Stieva-A). On se takođe koristi za treatiranje akutna promijelocitne leukemije (APL), i u prodaji je za tu indikaciju pod imenom Vesanoid. On je dostupan kao generički lek.

Proizvodnja

Jedan od mogućih sintetičkih puteva je:^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Lewin, Anita H.; Whaley, M. Glenn; Parker, Steven R.; Carroll, F. Ivy; Moreland, Charles G. (May 1982). „12-Carboxyretinoic acids. Synthesis and structure”. The Journal of Organic Chemistry 47 (10): 1799–1807. DOI:10.1021/jo00349a001.

Povezano

Spoljašnje veze

	Portal Medicina
	Portal Hemija

„Prescription Medications for Treating Acne”. American Academy of Dermatology.
Prescribing Information for Retin-A Micro^{[mrtav link]} Ortho
Tretinoin AHFS Consumer Medication Information at PubMed Health
Tretinoin Cream Prescribing Information Drugs.com

Šablon:Intracelularni hemoterapijski agensi

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Lewin, Anita H.; Whaley, M. Glenn; Parker, Steven R.; Carroll, F. Ivy; Moreland, Charles G. (May 1982). „12-Carboxyretinoic acids. Synthesis and structure”. The Journal of Organic Chemistry 47 (10): 1799–1807. DOI:10.1021/jo00349a001.

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