Menatetrenon

Menatetrenon
(IUPAC) ime
	2-metil-3-[(2Z,6E,10E)-3,7,11,15-tetrametilheksadeka-2,6,10,14-tetraen-1-il]naftohinon
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	863-61-6
ATC kod	nije dodeljen
PubChem	5282367
UNII	27Y876D139
KEGG	D00100
Hemijski podaci
Formula	C31H40O2
Mol. masa	444,648 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20+ ; Key: DKHGMERMDICWDU-GHDNBGIDSA-N
Sinonimi	3-metil-2-[(2Z,6E,10E)-3,7,11,15-tetrametilheksadeka-2,6,10,14-tetraenil]naftalen-1,4-dion
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	Oralno

Menatetrenon (MK4) je menahinonsko jedinjenje koji se koristi kao hemostatički agens i kao dopunska terapija za bol uzrokovan osteoporozom. On je u prodaji za tu tretman osteoporoze u Japanu pod imenom Glakaj.

Menatetrenon jedna od devet formi vitamina K₂.^[4]

MK4 se formira konverzijom vitamina K₁ u telu, testisima, pankreasu i arterijskim zidovima.^[5] Mada biohemijski put transformacije vitamina K₁ u MK4 nije potpuno razjašnjen, studije sugerišu da konverzija nije zavisna od bakterija u crevima.^[6]^[7]^[8]^[9] Tkiva koja akumuliraju velike količine MK4 imaju veliki kapacitet konvertovanja dostupnog K₁ u MK4.^[10]^[11]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Iwamoto J, Takeda T, Sato Y (December 2006). „Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis”. Nutr. Rev. 64 (12): 509–17. DOI:10.1111/j.1753-4887.2006.tb00184.x. PMID 17274493. ^{[mrtav link]}
↑ Shearer, Shearer MJ; Newman P. (2008). „Metabolism and cell biology of vitamin K”. Thrombosis and Haemostasis: 530–547. DOI:10.1160/TH08-03-0147.
↑ Davidson, RT; Foley AL, Engelke JA, Suttie JW (1998). „Conversion of Dietary Phylloquinone to Tissue Menaquinone-4 in Rats is Not Dependent on Gut Bacteria1”. Journal of Nutrition 128 (2): 220–223. PMID 9446847.
↑ Ronden, JE; Drittij-Reijnders M-J, Vermeer C, Thijssen HHW. (1998). „Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat”. Biochimica et Biophysica Acta (BBA) - General Subjects 1379 (1): 69–75. DOI:10.1016/S0304-4165(97)00089-5. PMID 9468334.
↑ Thijssen, HHW; Drittij-Reijnders MJ (1994). „Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4”. British Journal of Nutrition 72 (3): 415–425. DOI:10.1079/BJN19940043. PMID 7947656.
↑ Will, BH; Usui Y, Suttie JW (1992). „Comparative Metabolism and Requirement of Vitamin K in Chicks and Rats”. Journal of Nutrition 122 (12): 2354–2360. PMID 1453219.
↑ Davidson, RT; Foley AL, Engelke JA, Suttie JW (1998). „Conversion of Dietary Phylloquinone to Tissue Menaquinone-4 in Rats is Not Dependent on Gut Bacteria”. Journal of Nutrition 128 (2): 220–223. PMID 9446847.
↑ Ronden, JE; Drittij-Reijnders M-J, Vermeer C, Thijssen HHW (1998). „Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat”. Biochimica et Biophysica Acta (BBA) - General Subjects 1379 (1): 69–75. DOI:10.1016/S0304-4165(97)00089-5. PMID 9468334.

Povezano

Vitamin K
Filohinon (vitamin K₁)

Spoljašnje veze

	Portal Medicina
	Portal Hemija

„Glakay” (PDF). Eisai Co.. November 2009. Arhivirano iz originala na datum 2012-01-21. Pristupljeno 10. 1. 2012.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[pmid17274493-4] Iwamoto J, Takeda T, Sato Y (December 2006). „Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis”. Nutr. Rev. 64 (12): 509–17. DOI:10.1111/j.1753-4887.2006.tb00184.x. PMID 17274493. ^{[mrtav link]}

[5] Shearer, Shearer MJ; Newman P. (2008). „Metabolism and cell biology of vitamin K”. Thrombosis and Haemostasis: 530–547. DOI:10.1160/TH08-03-0147.

[6] Davidson, RT; Foley AL, Engelke JA, Suttie JW (1998). „Conversion of Dietary Phylloquinone to Tissue Menaquinone-4 in Rats is Not Dependent on Gut Bacteria1”. Journal of Nutrition 128 (2): 220–223. PMID 9446847.

[7] Ronden, JE; Drittij-Reijnders M-J, Vermeer C, Thijssen HHW. (1998). „Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat”. Biochimica et Biophysica Acta (BBA) - General Subjects 1379 (1): 69–75. DOI:10.1016/S0304-4165(97)00089-5. PMID 9468334.

[8] Thijssen, HHW; Drittij-Reijnders MJ (1994). „Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4”. British Journal of Nutrition 72 (3): 415–425. DOI:10.1079/BJN19940043. PMID 7947656.

[9] Will, BH; Usui Y, Suttie JW (1992). „Comparative Metabolism and Requirement of Vitamin K in Chicks and Rats”. Journal of Nutrition 122 (12): 2354–2360. PMID 1453219.

[10] Davidson, RT; Foley AL, Engelke JA, Suttie JW (1998). „Conversion of Dietary Phylloquinone to Tissue Menaquinone-4 in Rats is Not Dependent on Gut Bacteria”. Journal of Nutrition 128 (2): 220–223. PMID 9446847.

[11] Ronden, JE; Drittij-Reijnders M-J, Vermeer C, Thijssen HHW (1998). „Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat”. Biochimica et Biophysica Acta (BBA) - General Subjects 1379 (1): 69–75. DOI:10.1016/S0304-4165(97)00089-5. PMID 9468334.

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