Himozin
| Himozin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.23.4 | ||||||||
| CAS broj | 9001-98-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Himozin (EC 3.4.23.4, rennin) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Široka specifičnost poput pepsina A. Zgrušavanje mleka putem razlaganja jedne Ser-Phe105-Met-Ala veze u kapa-lancu kazeina
Ovaj neonatalni gastrični enzim efektivno zgrušava mleko i ima slabu opštu proteolitičku aktivnost.
- ↑ Foltmann, B. (1966). „A review of prorennin and rennin”. C. R. Trav. Lab. Carlsberg 35: 143-231. PMID 5330666.
- ↑ Harris, T.J.R., Lowe, P.A., Lyons, A., Thomas, P.G., Eaton, M.A.W., Millican, T.A., Patel, T.P., Bose, C.C., Carey, N.H. and Doel, M.T. (1982). „Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin”. Nucleic Acids Res. 10: 2177-2187. PMID 6283469.
- ↑ Visser, S., Slangen, C.J. and van Rooijen, P.J. (1987). „Peptide substrates for chymosin (rennin). Interaction sites in κ-casein-related sequences located outside the (103-108)-hexapeptide region that fits into the enzyme's active-site cleft”. Biochem. J. 244: 553-558. PMID 3128264.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.