O-1238
 | |
| IUPAC ime | |
|---|---|
(6aR)-3-[(Z)-6-azidoheks-2-enil]-6,6,9-trimetil-6a,7,10,10a-tetrahidrobenzo[c]hromen-1-ol | |
| Identifikatori | |
| ATC kod | none |
| PubChem | CID 10761489 |
| Hemijski podaci | |
| Formula | C22H29N3O2 |
| Molarna masa | 367,483 g/mol |
| |
O-1238 je lek koji je kanabinoidni derivat. On se koristi u naučnim istraživanjima. O-1238 je parcijalni agonist kanabinoidnog receptora CB1,[1] sa maksimalnom stimulacijom od 58.3%[2] i Ki vrednošću od 8,45 nM.[3]
Reference
[уреди | уреди извор]- ^ Griffin, Graeme; Wray, Emma J.; Martin, Billy R.; Abood, Mary E. (1999). „Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum”. British Journal of Pharmacology. 128 (3): 684—688. PMC 1571656
. PMID 10516649. doi:10.1038/sj.bjp.0702806.
- ^ Griffin, Graeme; Wray, Emma J.; Rorrer, William K.; Crocker, Peter J.; Ryan, William J.; Saha, Bijali; Razdan, Raj K.; Martin, Billy R.; Abood, Mary E. (1999). „An investigation into the structural determinants of cannabinoid receptor ligand efficacy”. British Journal of Pharmacology. 126 (7): 1575—1584. PMC 1565939
- ^ Ross, R. A.; Gibson, T. M.; Stevenson, L. A.; Saha, B.; Crocker, P.; Razdan, R. K.; Pertwee, R. G. (1999). „Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors”. British Journal of Pharmacology. 128 (3): 735—743. PMC 1571677
