Fenobarbital

Fenobarbital
IUPAC ime
	5-etil-5-phenil-1,3-diazinan-2,4,6-trion
Klinički podaci
Prodajno ime	Adonal, Aephenal, Agrypnal, Amylofene
Drugs.com	Monografija
Način primene	Oralno; Intramaskularno; Oralno;
Farmakokinetički podaci
Poluvreme eliminacije	53 do 118 sati
Identifikatori
CAS broj	50-06-6
ATC kod	N03AA01 (WHO), N03AA02
PubChem	CID 4763
IUPHAR/BPS	2804
DrugBank	DB01174
ChemSpider	4599
KEGG	C07434
ChEMBL	CHEMBL8069
Hemijski podaci
Formula	C12H12N2O3
Molarna masa	232.2353
	SMILES CCC1(C(=O)NC(=O)NC1=O)C1=CC=CC=C1; ;
	InChI InChI=1S/C12H12N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h3-7H,2H2,1H3,(H2,13,14,15,16,17) ; Key:DDBREPKUVSBGFI-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	174 °C (345 °F)

Fenobarbital je derivat barbituratne kiseline, koji deluje kao neselektivni depresant centralnog nervnog sistema. On promoviše vezivanje za inhibitorni tip receptora gama-aminobuterine kiseline, i moduliše protok hlorida kroz receptorske kanale. On snažno inhibira glutamatom indukovane depolarizacije.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Reference

^ Kwan P, Brodie MJ: Phenobarbital for the treatment of epilepsy in the 21st century: a critical review. Epilepsia. 2004 Sep;45(9):1141-9. PMID 15329080
^ Taylor S, Tudur Smith C, Williamson PR, Marson AG: Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. Cochrane Database Syst Rev. 2001;(4):CD002217. PMID 11687150
^ Tudur Smith C, Marson AG, Williamson PR: Carbamazepine versus phenobarbitone monotherapy for epilepsy. Cochrane Database Syst Rev. 2003;(1):CD001904. PMID 12535420
^ Kalviainen R, Eriksson K, Parviainen I: Refractory generalised convulsive status epilepticus : a guide to treatment. CNS Drugs. 2005;19(9):759-68. PMID 16142991
^ Booth D, Evans DJ: Anticonvulsants for neonates with seizures. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004218. PMID 15495087
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

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