از ویکیپدیا، دانشنامهٔ آزاد
گیرندهٔ چشایی نوع ۲، عضو ۹ (انگلیسی : Taste receptor type 2 member 9 ) یک پروتئین است که در انسان توسط ژن «TAS2R9 » کُدگذاری میشود.[ ۲] [ ۳] [ ۴]
این ژن و پروتئینش در حسِ چشایی در انسان و شناخت مزه تلخی نقش دارند.
وجود پُلیمورفیسم در این ژن، با تشخیص مزهٔ تلخ در اسسولفام پتاسیم در ارتباط است.[ ۵]
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell . 100 (6): 693–702. doi :10.1016/S0092-8674(00)80705-9 . PMID 10761934 . ↑ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature . 404 (6778): 601–4. doi :10.1038/35007072 . PMID 10766242 . ↑ "Entrez Gene: TAS2R9 taste receptor, type 2, member 9" .↑ Allen AL, McGeary JE, Knopik VS, Hayes JE (2013). "Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31" . Chem. Senses . 38 (5): 379–89. doi :10.1093/chemse/bjt017 . PMC 3657735 PMID 23599216 .
Kinnamon SC (2000). "A plethora of taste receptors". Neuron . 25 (3): 507–10. doi :10.1016/S0896-6273(00)81054-5 . PMID 10774719 . Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem . 277 (1): 1–4. doi :10.1074/jbc.R100054200 . PMID 11696554 . Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol . 12 (4): 366–71. doi :10.1016/S0959-4388(02)00345-8 . PMID 12139982 . Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell . 100 (6): 703–11. doi :10.1016/S0092-8674(00)80706-0 . PMID 10761935 . Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell . 112 (3): 293–301. doi :10.1016/S0092-8674(03)00071-0 . PMID 12581520 . Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes" . Mol. Biol. Evol . 22 (3): 432–6. doi :10.1093/molbev/msi027 . PMID 15496549 . Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates" . Genetics . 170 (1): 313–26. doi :10.1534/genetics.104.037523 . PMC 1449719 PMID 15744053 .
