Kaltzitonina

Kaltzitonina
Egitura erabilgarri
PDB	Ortologoaren bilaketa: PDBe RCSB
PDB ID kodeen zerrenda
	2JXZ,%%s1LS7
Identifikatzaileak
Aliasak	CALCA (HUGO), CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1
Kanpoko IDak	OMIM: 114130 MGI: 2151253 HomoloGene: 88401 GeneCards: CALCA OMA: CALCA - orthologs
Drogaren xedea
	Calcitonin receptor
Genearen kokapena (Giza)
Kr.	Kromosoma 11 (gizakia)
Amaiera	14.972.351 bp
Genearen kokapena (Sagua)
Kr.	Kromosoma 7 (sagua)
Amaiera	114.235.592 bp
RNA adierazpena eredua
	Gehien adierazita
	spinal ganglia ; ; trigeminal ganglion ; ; koadrizeps muskulu femoral; ; vastus lateralis muscle ; ; cerebellar vermis ; ; Langerhansen irla; ; human kidney ; ; Epithelium of choroid plexus ; ; Atzeko muskulu tibial ; ; right lobe of liver ;
	Gehien adierazita
	Aurpegi nerbioaren nukleo; ; neurona motor ; ; lumbar spinal ganglion ; ; anterior horn of spinal cord ; ; lactiferous gland ; ; Trakea; ; trigeminal ganglion ; ; enbrioi; ; enbrioi; ; vestibular membrane of cochlear duct ;
	Erreferentziazko adierazpen datu gehiago
	; ; ; ;
	Erreferentziazko adierazpen datu gehiago
Geen ontologia
Funtzio molekularra	hormone activity ; calcitonin receptor binding ; proteina lotura ; identical protein binding ; signaling receptor binding ; protein-containing complex binding ;
Zelularen osagaia	zitoplasma ; intrazelular ; zelulaz kanpoko eremu ; Axoi ; terminal bouton ; neuronal cell body ; neuron projection ; zelula nukleo ; extracellular space ;
Prozesu biologikoa	cellular response to nerve growth factor stimulus ; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway ; negative regulation of smooth muscle contraction ; regulation of heart contraction ; monocyte chemotaxis ; negative regulation of blood pressure ; positive regulation of cytosolic calcium ion concentration ; cellular response to tumor necrosis factor ; Giza zahartze ; basodilatazio ; zelulako kaltzio ioi homeostasia ; response to heat ; negative regulation of nervous system process ; positive regulation of ossification ; activation of adenylate cyclase activity ; regulation of heart rate ; detection of temperature stimulus involved in sensory perception of pain ; negative regulation of ossification ; response to pain ; artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure ; feeding behavior ; inflammatory response ; neuropeptide signaling pathway ; negative regulation of transcription, DNA-templated ; activation of protein kinase activity ; embryo implantation ; negative regulation of bone resorption ; regulation of signaling receptor activity ; G proteina errezeptore akoplatuaren komunikazio bidea ; adenylate cyclase-activating G protein-coupled receptor signaling pathway ; regulation of cytosolic calcium ion concentration ; leukocyte cell-cell adhesion ; G protein-coupled receptor internalization ; positive regulation of interleukin-1 alpha production ; response to yeast ; negative regulation of osteoclast differentiation ; cell-cell signaling ; antibacterial humoral response ; positive regulation of macrophage differentiation ; receptor internalization ; regulation of blood pressure ; protein phosphorylation ; vasculature development ; defense response to Gram-negative bacterium ; endothelial cell proliferation ; positive regulation of interleukin-8 production ; nervous system process involved in regulation of systemic arterial blood pressure ; negative regulation of calcium ion transport into cytosol ; berezko sistema immune ; endothelial cell migration ; antifungal humoral response ; defense response to Gram-positive bacterium ; antimicrobial humoral immune response mediated by antimicrobial peptide ; amylin receptor signaling pathway ; calcitonin gene-related peptide receptor signaling pathway ;
	Iturburuak:Amigo / QuickGO
Ortologoak
	796
	12310
	ENSG00000110680
	ENSMUSG00000030669
	P06881
	P70160; Q99JA0
	NM_001033952; NM_001033953; NM_001741; NM_001378949; NM_001378950
	NM_001033954; NM_007587; NM_001289444; NM_001305616
	NP_001029125.1
	NP_001029126; NP_001276373; NP_001292545; NP_031613; NP_001029126.1; NP_001276373.1
	Wikidata
Ikusi/Editatu giza genea	Ikusi/Editatu saguaren genea

Kaltzitonina tiroide guruinaren zelula parafolikularrek sintetizatzen duten hormona da. Hormona honek odoleko kaltzio eta fosfato kontzentrazioak murrizten ditu.

Odolean kaltzio kontzentrazioaren igoera bat ematen denean tiroidea aktibatu egiten da eta kaltzitonina jariatzen hasten da. Kaltzitoninak efektu fisiologiko desberdinak izango ditu:

Giltzurrunean kaltzio eta fosfatoaren birxurgapena gutxitzen du.
Hezurretan osteoklastoak inhibitu eta osteoblastoak aktibatzen ditu. Horren eraginez, hezurraren birxurgapena edo erreabsortzioa moteltzen da eta kaltzioa odoletik hezurretara pasatzen da.

Izokinaren kaltzitonina hainbat gaixotasunen tratamenduan erabili izan da:

Erreferentziak

↑ Fisikoki elkarreragiten duten drogak calcitoninikusi/editatu erreferentziak wikidatuetan. .
↑ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110680 - Ensembl, May 2017
↑ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030669 – Ensembl, May 2017
↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

Kanpo estekak

Datuak: Q315860
Multimedia: Calcitonin / Q315860

[1] Fisikoki elkarreragiten duten drogak calcitoninikusi/editatu erreferentziak wikidatuetan. .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000110680 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000030669 – Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

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