Trab domain containing 2b

TraB domain containing 2B is a protein that in humans is encoded by the TRABD2B gene.

TRABD2B
Identifiers
Aliases	TRABD2B, TIKI2, TraB domain containing 2B
External IDs	OMIM: 614913; MGI: 3650152; HomoloGene: 85034; GeneCards: TRABD2B; OMA:TRABD2B - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p33 Start 47,760,528 bp End 47,997,385 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D1|4 Start 114,263,921 bp End 114,472,295 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries right coronary artery left coronary artery ascending aorta Descending thoracic aorta right auricle human kidney sural nerve right lobe of liver Top expressed in myocardium of ventricle interventricular septum human kidney right kidney otolith organ utricle external carotid artery calvaria internal carotid artery aorta More reference expression data BioGPS n/a
Gene ontology Molecular function Wnt-protein binding peptidase activity metalloendopeptidase activity protein binding metallopeptidase activity hydrolase activity metal ion binding Cellular component integral component of membrane integral component of organelle membrane plasma membrane integral component of plasma membrane membrane Biological process negative regulation of Wnt signaling pathway Wnt signaling pathway proteolysis positive regulation of protein oxidation positive regulation of protein oligomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 388630 666048 Ensembl ENSG00000269113 ENSMUSG00000070867 UniProt A6NFA1 B1ATG9 RefSeq (mRNA) NM_001194986 NM_001085549 RefSeq (protein) NP_001181915 NP_001079018 Location (UCSC) Chr 1: 47.76 – 48 Mb Chr 4: 114.26 – 114.47 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Li R, Liu J, Wu H, Liu L, Wang L, Zhang S (July 2014). "TIKI2 suppresses growth of osteosarcoma by targeting Wnt/β-catenin pathway". Mol. Cell. Biochem. 392 (1–2): 109–16. doi:10.1007/s11010-014-2023-5. PMID 24771064. S2CID 10974823.
• Zhang X, MacDonald BT, Gao H, Shamashkin M, Coyle AJ, Martinez RV, He X (January 2016). "Characterization of Tiki, a New Family of Wnt-specific Metalloproteases". J. Biol. Chem. 291 (5): 2435–43. doi:10.1074/jbc.M115.677807. PMC 4732225. PMID 26631728.