Talk:Base excision repair

Untitled

BER does not occur only during replication! It can occur throughout the cell cycle and is important to repair single-strand breaks before replication so that they don't result in lethal double-strand breaks. —Preceding unsigned comment added by 130.237.85.123 (talk) 13:29, 11 March 2008 (UTC)

betty, 25 Januar 2009

the article is not clearly arranged. Maybe a scheme about the single glycosylases would be more instructive. And a figure about the basic mechanism would be nice ,too. thanks! —Preceding unsigned comment added by 193.174.73.60 (talk) 15:36, 25 January 2009 (UTC)

Short and long patch repair

The short and long pair repair section should actually belong here, not in DNA mismatch repair Temporal User (Talk) 05:37, 11 February 2009 (UTC)

I don't agree. Short patch in MMR is 10 nucleotides and long patch is a few kbases, while BER short patch is 1 nucleotide and long patch is no longer than 15 nucleotides. They are clearly different and as far as I know they MMR is coupled to replication and don't involve any of the BER proteins. Sniffe35 (talk) 11:56, 17 February 2009 (UTC)

I agree with Sniffe35. The BER article definitely needs a section describing the short and long patch repair pathways, but the concept is fundamentally different than the related concept in MMR, so a merge would not work. I'll work on this article as soon as I have some free time - it's currently in pretty bad shape. Amazinglarry (talk) 20:47, 17 February 2009 (UTC)

glycosylases

Perhaps we should divide the section of glycosylases into bifunctional and monofunctional? I'll help update this article when I have more time! It is desperately in need of a section about DNA synthesis and ligation... Single-strand break repair needs to be mentioned here, as well as end processing enzymes and APE1. Sniffe35 (talk) 16:02, 28 April 2009 (UTC)

does anyone else think it odd that the section on DNA glycosylases here ias far far longer than the actual article on DNA glycosylases that it links to? Philman132 (talk) 16:22, 5 May 2009 (UTC)

Yeah, I moved it into the DNA glycosylases article today. I am currently heavily editing this article to try to address the cleanup issues. So far I've mostly just changed the framework and organization, I'll continue adding detail and references in the coming days. Amazinglarry (talk) 18:18, 10 July 2009 (UTC)

Rewrite of this article

Over the last few days I've done a major rewrite of this article to address the above issues. I tried to make the article into more of an overview (previously it had a lot of detailed information on specific glycosylases but little overview-type material on the pathway as a whole that would be more appropriate for an encyclopedia). Please take a look at it and make suggestions here if there's anything you'd like to see added/removed/expanded/etc. If anyone wants to help with adding references please jump in! Amazinglarry (talk) 21:06, 15 July 2009 (UTC)

WOW, great work Amazinglarry! It made my day to see how much better this article is now. There might be a point to add repair of direct SSBs as that includes the short and long patch pathways as well as the end processing enzymes and PARP1. I'm not sure if this would be a separate section though, nowadays many researchers distinguish between SSB repair and BER? Sniffe35 (talk) 13:56, 4 May 2010 (UTC)

Thanks for your comments Sniffe35! Direct repair of SSBs is mentioned under "lesions processed by BER" but it wouldn't be a bad idea to expand that a little. PARP1 is definitely missing and needs to be added somewhere. Next time I sit down and work on this article I'll try to incorporate your suggestions. In the meantime, feel free to make the edits yourself if you feel like it. Amazinglarry (talk) 21:06, 5 May 2010 (UTC)

Evolution

Which organisms do BER? Which parts of it? Exceptions? Importance in organims in highly oxidative environments, redundancies there. --Ayacop (talk) 15:04, 8 August 2011 (UTC)

Parp1 and Aag

As well as mentioning Parp1, as suggested above, should we also mention Aag as per How to minimize the side effects of cancer treatment. Also Defining the functional footprint for recognition and repair of deaminated DNA.
alkyladenine glycosylase is mentioned in deamination but not here. - Rod57 (talk) 15:26, 7 April 2013 (UTC)