Probable methyltransferase TARBP1 is an enzyme that in humans is encoded by the TARBP1 gene .[ 5] [ 6]
HIV-1 , the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II . This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation . Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined.[ 6]
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