NLRP6

NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.

NLRP6
Identifiers
Aliases	NLRP6, AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5, NLR family, pyrin domain containing 6, NLR family pyrin domain containing 6
External IDs	OMIM: 609650; MGI: 2141990; HomoloGene: 15881; GeneCards: NLRP6; OMA:NLRP6 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.5 Start 278,407 bp End 285,388 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F5 Start 140,500,815 bp End 140,509,105 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte right lobe of liver spleen appendix duodenum left uterine tube right lung monocyte lymph node Top expressed in Paneth cell jejunum crypt of lieberkuhn of small intestine left lobe of liver duodenum colon ileum right kidney intestinal villus left colon More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding vasopressin receptor activity ATP binding Cellular component cytoplasm nuclear membrane membrane plasma membrane inflammasome complex nucleus Biological process response to bacterium immune system process wound healing regulation of mucus secretion negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of immune response regulation of autophagy negative regulation of toll-like receptor signaling pathway negative regulation of inflammatory response to antigenic stimulus regulation of inflammatory response negative regulation of MAPK cascade negative regulation of ERK1 and ERK2 cascade innate immune response inflammatory response G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 171389 101613 Ensembl ENSG00000174885 ENSMUSG00000038745 UniProt P59044 Q91WS2 RefSeq (mRNA) NM_001276700 NM_138329 NM_001081389 NM_133946 RefSeq (protein) NP_001263629 NP_612202 NP_598707 Location (UCSC) Chr 11: 0.28 – 0.29 Mb Chr 7: 140.5 – 140.51 Mb PubMed search
Wikidata
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Further reading

• Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. S2CID 11183658.
• Albrecht M, Domingues FS, Schreiber S, Lengauer T (2003). "Identification of mammalian orthologs associates PYPAF5 with distinct functional roles". FEBS Lett. 538 (1–3): 173–7. Bibcode:2003FEBSL.538..173A. doi:10.1016/S0014-5793(03)00161-3. PMID 12633874. S2CID 7730963.
• Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
• Wang L, Manji GA, Grenier JM, et al. (2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J. Biol. Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.