Cyclopropanol

Cyclopropanol
Names
	Preferred IUPAC name Cyclopropanol
	Other names Cyclopropyl alcohol, Hydroxycyclopropane
Identifiers
CAS Number	16545-68-9 ;
3D model (JSmol)	Interactive image;
ChemSpider	109961 ;
ECHA InfoCard	100.217.724
PubChem CID	123361;
CompTox Dashboard (EPA)	DTXSID40167949 ;
	InChI InChI=1S/C3H6O/c4-3-1-2-3/h3-4H,1-2H2 Key: YOXHCYXIAVIFCZ-UHFFFAOYSA-N ;
	SMILES OC1CC1;
Properties
Chemical formula	C3H6O
Molar mass	58.080 g·mol−1
Density	0.917 g/mL
Boiling point	101 to 102 °C (214 to 216 °F; 374 to 375 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Cyclopropanol is an organic compound with the chemical formula C₃H₆O. It contains a cyclopropyl group with a hydroxyl group attached to it. The compound is highly unstable due to the three-membered ring, and is susceptible to reactions that open the ring. It is highly prone to rearrangement, undergoing structural isomerization to form propanal.^[3]^[4] This property is useful synthetically: cyclopropanol can be used as a synthon for the homoenolate of propanal. The chemical is also useful as a reagent to introduce a cyclopropyl group into ester, sulfate, and amine linkages. The resulting cyclopropyl-containing compounds have been used in investigations of potential antiviral drugs^[5] and of modulators of protein trafficking.^[6]

References

^ Roberts, J. D.; Chambers, V. C. (1951). "Small-Ring Compounds. VI. Cyclopropanol, Cyclopropyl Bromide and Cyclopropylamine". J. Am. Chem. Soc. 73 (7): 3176–3179. doi:10.1021/ja01151a053.
^ Jongejan, J. A.; Duine, J. A. (1987). "Enzymatic hydrolysis of cyclopropyl acetate. A facile method for medium- and large-scale preparations of cyclopropanol". Tetrahedron Lett. 28 (24): 2767–2768. doi:10.1016/S0040-4039(00)96204-X.
^ Magrane, J. K.; Cottle, D. L. (1942). "The Reaction of Epichlorohydrin with the Grignard Reagent". J. Am. Chem. Soc. 64 (3): 484–487. doi:10.1021/ja01255a004.
^ Stahl, G. W.; Cottle, D. L. (1943). "The Reaction of Epichlorohydrin with the Grignard Reagent. Some Derivatives of Cyclopropanol". J. Am. Chem. Soc. 65 (9): 1782–1783. doi:10.1021/ja01249a507.
^ WO application 2009005677, Cottell, J. J.; Link, J. O. Schroeder, S. D.; Taylor, J.; Tse, W.; Vivian, R. W.; Yang, Z.-Y., "Antiviral compounds", published 2009-01-08
^ WO application 2009062118, Bulawa, C. E.; Devit, M.; Elbaum, D., "Modulators of protein trafficking", published 2009-05-14

[roberts-1] Roberts, J. D.; Chambers, V. C. (1951). "Small-Ring Compounds. VI. Cyclopropanol, Cyclopropyl Bromide and Cyclopropylamine". J. Am. Chem. Soc. 73 (7): 3176–3179. doi:10.1021/ja01151a053.

[enz_synth-2] Jongejan, J. A.; Duine, J. A. (1987). "Enzymatic hydrolysis of cyclopropyl acetate. A facile method for medium- and large-scale preparations of cyclopropanol". Tetrahedron Lett. 28 (24): 2767–2768. doi:10.1016/S0040-4039(00)96204-X.

[magrane-3] Magrane, J. K.; Cottle, D. L. (1942). "The Reaction of Epichlorohydrin with the Grignard Reagent". J. Am. Chem. Soc. 64 (3): 484–487. doi:10.1021/ja01255a004.

[stahl-4] Stahl, G. W.; Cottle, D. L. (1943). "The Reaction of Epichlorohydrin with the Grignard Reagent. Some Derivatives of Cyclopropanol". J. Am. Chem. Soc. 65 (9): 1782–1783. doi:10.1021/ja01249a507.

[cottell_patent-5] WO application 2009005677, Cottell, J. J.; Link, J. O. Schroeder, S. D.; Taylor, J.; Tse, W.; Vivian, R. W.; Yang, Z.-Y., "Antiviral compounds", published 2009-01-08

[bulawa_patent-6] WO application 2009062118, Bulawa, C. E.; Devit, M.; Elbaum, D., "Modulators of protein trafficking", published 2009-05-14

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