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Peter Grootenhuis

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Peter Grootenhuis (March 1960 – August 2019) was a Dutch-American Medicinal Chemist. Grootenhuis was the Project Leader and Co-Inventor of Ivacaftor (VX-770), the first CFTR potentiator FDA approved drug to treat the underlying cause of Cystic Fibrosis (CF) in patients with certain mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene (primarily the G551D mutation.[1]), who account for 4-5% of CF cases. Grootenhuis also led the Vertex team to subsequent discovery of Orkambi, the combination of Ivacaftor and Lumacaftor(VX-809), approved to treat CF in people with two copies of the F508del mutation (~ 50% of CF patients).[2] Most recently, Grootenhuis's team discovered Tezacaftor (VX-661) and Elexacaftor (VX-445),[3] which in combination with Ivacaftor are the components of Trikafta, a drug approved by the FDA in 2019 to treat CF in more than 90% of CF patients.[4] For Grootenhuis’ contributions to the discovery of these compounds, he was awarded the 2018 IUPAC Richter Prize,[5] the American Chemical Society’s 2013 Heroes of Chemistry Award,[6] and inducted into the American Chemical Society Division of Medicinal Chemistry Hall of Fame.[7] Grootenhuis has contributed to the discovery of over 11 clinical candidates, co-authored more than 100 peer reviewed papers and is inventor of 65 + U.S Patents, and more than 50 EU Patents.[8]

Biography

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Grootenhuis completed both his B.Sc and M.Sc in chemistry at the University of Utrecht (1978–1983).[9] He then went on to complete his PhD in organic chemistry under the guidance of David Reinhoudt (1983-1987)[10]

After finishing his PhD, Grootenhuis completed a postdoctoral fellowship at the University of California, San Francisco on a NATO Fellowship, under Peter Kollman (1987–1989).[11] Consequently, he went on to work at Organon (now Akzo-Nobel) for several years, simultaneously holding a part-time Professorship at the University of Groningen and doing a short sabbatical with Martin Karplus at Harvard University (1991).[12] After nine years at Organon, Grootenhuis moved to San Diego, CA to work for CombiChem as Vice President of Computational Chemistry in 1998.[13] Grootenhuis stayed with the company through several corporate mergers by DuPont Pharmaceuticals, Bristol-Myers Squibb, and lastly Deltagen Inc. After Deltagen folded, Grootenhuis worked for 19 years at Vertex Pharmaceuticals, notably as the Project Leader for the CFTR modulator project.[14] From 2005 to 2016, Grootenhuis held a faculty appointment at the Free University of Amsterdam (VU), serving as the Nauta Chair (Professor Emeritus) of Virtual Drug Screening & Design.[15]

Grootenhuis was a lifelong karate student and received multiple black belts.[16] He was specifically interested in the Physics of Kobudō, an ancient Okinawan weapons-based martial arts discipline, eventually writing a book on the subject in 2018. He was awarded the title of Sensei in March 2019 by Grandmaster Jerry Devine of Pacific Martial Arts[17]

Awards

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Professional Affiliations

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Institutions

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References

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  1. ^ Sermet-Gaudelus, Isabelle (2013-03-01). "Ivacaftor treatment in patients with cystic fibrosis and the G551D-CFTR mutation". European Respiratory Review. 22 (127): 66–71. doi:10.1183/09059180.00008512. ISSN 0905-9180. PMC 9487423. PMID 23457167. S2CID 16564925.
  2. ^ "Our Scientists Power Science | Vertex Pharmaceuticals". www.vrtx.com. Retrieved 2020-09-30.
  3. ^ "Tezacaftor/ivacaftor in people with cystic fibrosis heterozygous for minimal function CFTR mutations". MDLinx. Retrieved 2020-07-21.
  4. ^ Commissioner, Office of the (2020-03-24). "FDA approves new breakthrough therapy for cystic fibrosis". FDA. Retrieved 2020-07-21.
  5. ^ "Peter D.J. Grootenhuis is awarded the 2018 IUPAC-Richter Prize". IUPAC | International Union of Pure and Applied Chemistry. 2018-01-23. Retrieved 2020-07-21.
  6. ^ "New 'Heroes of Chemistry' developed products that improve health and protect food supply". American Chemical Society. Retrieved 2020-07-21.
  7. ^ "MEDI Hall of Fame Inductees". www.acsmedchem.org. Retrieved 2020-07-21.
  8. ^ "Peter Grootenhuis, Ph.D." www.acsmedchem.org. Retrieved 2020-07-21.
  9. ^ "Grootenhuis, Peter". American Chemical Society. Retrieved 2020-09-30.
  10. ^ "Chemistry Tree - Peter D.J. Grootenhuis". academictree.org. Retrieved 2020-07-21.
  11. ^ "Grootenhuis, Peter". American Chemical Society. Retrieved 2020-09-30.
  12. ^ Grootenhuis, Peter D. J.; Karplus, Martin (1996-02-01). "Functionality map analysis of the active site cleft of human thrombin". Journal of Computer-Aided Molecular Design. 10 (1): 1–10. Bibcode:1996JCAMD..10....1G. doi:10.1007/BF00124460. ISSN 1573-4951. PMID 8786410. S2CID 9166796.
  13. ^ "Peter Grootenhuis, Ph.D." www.acsmedchem.org. Retrieved 2020-09-30.
  14. ^ Miller, Julann. "2019 Distinguished Scientists Award Banquet" (PDF). San Diego ACS Chapter. Retrieved September 30, 2020.
  15. ^ "Farewell Seminar by Peter Grootenhuis - [okt-dec] - Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam". aimms.vu.nl. Retrieved 2020-07-21.
  16. ^ "PETER GROOTENHUIS: QUITTING IS NOT AN OPTION!". www.maiahub.com. Retrieved 2020-07-22.
  17. ^ Arts, Pacific Martial (2019-09-18). "The Gathering to honor Peter Grootenhuis". Pacific Martial Arts. Retrieved 2020-07-22.
  18. ^ "New 'Heroes of Chemistry' developed products that improve health and protect food supply". American Chemical Society. Retrieved 2020-07-21.
  19. ^ "Press release Peter D.J. Grootenhuis, Ph.D. is Awarded the 2018 IUPAC-Richter Prize". www.richter.hu. Retrieved 2020-07-21.
  20. ^ "MEDI Hall of Fame Inductees". www.acsmedchem.org. Retrieved 2020-07-21.
  21. ^ "San Diego Chapter of the American Chemical Society October 2019 Newsletter" (PDF). ACS San Diego Chapter. Retrieved 2020-07-21.