PTH

PTH
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1BWX, 1ET1, 1FVY, 1HPH, 1HPY, 1HTH, 1ZWA, 1ZWB, 1ZWD, 1ZWE, 1ZWF, 1ZWG, 2L1X, 3C4M
Dynodwyr
Cyfenwau	PTH, PTH1, parathyroid hormone, Parathyroid hormone, FIH1
Dynodwyr allanol	OMIM: 168450 HomoloGene: 266 GeneCards: PTH
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • hormone activity; • parathyroid hormone receptor binding; • type 1 parathyroid hormone receptor binding; • protein N-terminus binding; • receptor ligand activity; • peptide hormone receptor binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• intracellular anatomical structure; • extracellular region; • extracellular space;
Prosesau biolegol	• positive regulation of signal transduction; • positive regulation of cell proliferation in bone marrow; • positive regulation of osteoclast proliferation; • response to fibroblast growth factor; • hormone-mediated apoptotic signaling pathway; • cAMP metabolic process; • response to ethanol; • response to parathyroid hormone; • skeletal system development; • positive regulation of ossification; • response to lead ion; • response to nutrient levels; • G protein-coupled receptor signaling pathway; • response to vitamin D; • negative regulation of apoptotic process in bone marrow cell; • GO:1901227 negative regulation of transcription by RNA polymerase II; • cellular macromolecule biosynthetic process; • cellular calcium ion homeostasis; • homeostasis of number of cells within a tissue; • response to cadmium ion; • Rho protein signal transduction; • positive regulation of glucose import; • positive regulation of glycogen biosynthetic process; • bone resorption; • positive regulation of bone mineralization; • regulation of gene expression; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • cell-cell signaling; • activation of phospholipase C activity; • negative regulation of chondrocyte differentiation; • positive regulation of inositol phosphate biosynthetic process; • negative regulation of bone mineralization involved in bone maturation; • regulation of signaling receptor activity; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • calcium ion transport; • magnesium ion homeostasis; • bone mineralization; • phosphate ion homeostasis; • calcium ion homeostasis; • negative regulation of calcium ion transport;
	Sources:Amigo / QuickGO
Orthologau
	5741
	n/a
	ENSG00000152266
	n/a
	P01270
	n/a
	NM_000315; NM_001316352
	n/a
	NP_000306; NP_001303281
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTH yw PTH a elwir hefyd yn Parathyroid hormone (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTH.

PTH1

Llyfryddiaeth

"Association of parathyroid hormone and vitamin D with untreated hypertension: Is it different in white-coat or sustained hypertension?". PLoS One. 2017. PMID 29176783.
"Influence of concurrent chronic kidney disease on intraoperative parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism. ". Surgery. 2018. PMID 29128188.
"The effect of parathyroid hormone on the uptake and retention of 25-hydroxyvitamin D in skeletal muscle cells. ". J Steroid Biochem Mol Biol. 2017. PMID 28104493.
"Adenomatous Colon Polyps in Diabetes: Increased Prevalence in Patients with Chronic Kidney Disease and Its Association with Parathyroid Hormone. ". Ann Clin Lab Sci. 2016. PMID 27993873.
"Genetic Variants Associated with Circulating Parathyroid Hormone.". J Am Soc Nephrol. 2017. PMID 27927781.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PTH - Cronfa NCBI

[1]

[2]