PAK4

PAK4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2BVA, 2CDZ, 2J0I, 2OV2, 2Q0N, 2X4Z, 4APP, 4FIE, 4FIF, 4FIG, 4FIH, 4FII, 4FIJ, 4JDH, 4JDI, 4JDJ, 4JDK, 4L67, 4NJD, 4O0V, 4O0X, 4O0Y, 5BMS, 4XBU, 4XBR
Dynodwyr
Cyfenwau	PAK4, p21 (RAC1) activated kinase 4
Dynodwyr allanol	OMIM: 605451 HomoloGene: 4300 GeneCards: PAK4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • cadherin binding involved in cell-cell adhesion • protein serine/threonine kinase activity Cydrannau o'r gell • cytoplasm • Golgi apparatus • focal adhesion Prosesau biolegol • phosphorylation • GO:1904579 cellular response to organic cyclic compound • protein phosphorylation • cell growth • dendritic spine development • cytoskeleton organization • cell cycle • cell population proliferation • cell migration • GO:0072468 signal transduction • GO:0097285 apoptotic process • cell-cell adhesion • Rho protein signal transduction • regulation of mitotic cell cycle • actin cytoskeleton organization • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process • regulation of MAPK cascade • regulation of cell growth • positive regulation of angiogenesis • negative regulation of endothelial cell apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10298	n/a
Ensembl	ENSG00000130669	n/a
UniProt	O96013	n/a
RefSeq (mRNA)	NM_001014831 NM_001014832 NM_001014833 NM_001014834 NM_001014835 NM_005884 NM_001394501	n/a
RefSeq (protein)	NP_001014831 NP_001014832 NP_001014834 NP_001014835 NP_005875	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PAK4 yw PAK4 a elwir hefyd yn P21 (RAC1) activated kinase 4 a Serine/threonine-protein kinase PAK 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.2.

Llyfryddiaeth

• "Prognostic significance of PAK4 expression in gastric cancer. ". J Clin Pathol. 2016. PMID 26614788.
• "PAK4 confers the malignance of cervical cancers and contributes to the cisplatin-resistance in cervical cancer cells via PI3K/AKT pathway. ". Diagn Pathol. 2015. PMID 26411419.
• "Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling. ". Oncotarget. 2017. PMID 28407679.
• "Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma. ". Blood. 2017. PMID 28096095.
• "The P21-activated kinase PAK4 is implicated in fatty-acid potentiation of insulin secretion downstream of free fatty acid receptor 1.". Islets. 2016. PMID 27700527.