KDM5A

KDM5A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2JXJ, 2KGG, 2KGI, 3GL6, 5C11, 5E6H, 5IWF, 5IVV, 5ISL, 5CEH, 5IVB
Dynodwyr
Cyfenwau	KDM5A, RBBP-2, RBBP2, RBP2, JARID1A, lysine demethylase 5A
Dynodwyr allanol	OMIM: 180202 HomoloGene: 3419 GeneCards: KDM5A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001105 transcription coactivator activity • chromatin binding • dioxygenase activity • metal ion binding • GO:0001948, GO:0016582 protein binding • oxidoreductase activity • chromatin DNA binding • histone demethylase activity • core promoter sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • histone H3-methyl-lysine-9 demethylase activity • histone H3-tri/di/monomethyl-lysine-4 demethylase activity • zinc ion binding • methylated histone binding • GO:0031493 histone binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific Cydrannau o'r gell • cyclin-dependent protein kinase activating kinase holoenzyme complex • nucleoplasm • protein-DNA complex • nucleolus • cnewyllyn cell • histone methyltransferase complex Prosesau biolegol • male gonad development • GO:0009373 regulation of transcription, DNA-templated • proses rythmig • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • circadian regulation of gene expression • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • multicellular organism development • spermatogenesis • negative regulation of histone deacetylase activity • histone H3-K9 demethylation • histone H3-K4 demethylation • histone H3-K4 demethylation, trimethyl-H3-K4-specific • regulation of DNA-binding transcription factor activity • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • chromatin remodeling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5927	n/a
Ensembl	ENSG00000073614	n/a
UniProt	P29375	n/a
RefSeq (mRNA)	NM_005056 NM_001042603	n/a
RefSeq (protein)	NP_001036068	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KDM5A yw KDM5A a elwir hefyd yn Lysine-specific demethylase 5A a Lysine demethylase 5a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p13.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KDM5A.

• RBP2
• RBBP2
• RBBP-2

Llyfryddiaeth

• "Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex. ". J Biol Chem. 2014. PMID 25190814.
• "Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells. ". Oncotarget. 2014. PMID 25015565.
• "Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair. ". PLoS One. 2016. PMID 27253695.
• "The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma. ". Cell Cycle. 2015. PMID 26566863.
• "Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism.". Nat Commun. 2015. PMID 25686748.