CAMK1D

CAMK1D
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2JC6
Identifikatori
Aliasi	CAMK1D
Vanjski ID-jevi	OMIM: 607957 MGI: 2442190 HomoloGene: 121858 GeneCards: CAMK1D
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	12,835,545 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	5,719,326 bp
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • nucleotide binding; • protein kinase activity; • kinase activity; • protein serine/threonine kinase activity; • catalytic activity; • ATP binding; • calmodulin-dependent protein kinase activity; • calmodulin binding;
Ćelijska komponenta	• jedro; • citoplazma;
Biološki proces	• regulation of granulocyte chemotaxis; • positive regulation of phagocytosis; • Fosforilacija; • negative regulation of apoptotic process; • regulation of dendrite development; • nervous system development; • protein phosphorylation; • positive regulation of CREB transcription factor activity; • positive regulation of apoptotic process; • metabolizam; • inflammatory response; • positive regulation of respiratory burst; • positive regulation of neutrophil chemotaxis; • positive regulation of neuron projection development; • GO:0035404 peptidyl-serine phosphorylation; • peptidyl-threonine phosphorylation; • GO:0007243 intracellular signal transduction;
	Izvori:Amigo / QuickGO
Ortolozi
	57118
	227541
	ENSG00000183049
	ENSMUSG00000039145
	Q8IU85
	Q8BW96
	NM_020397; NM_153498; NM_001351032
	NM_001290374; NM_001290375; NM_001290376; NM_177343
	NP_065130; NP_705718; NP_001337961
	NP_001277303; NP_001277304; NP_001277305; NP_796317
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Kalcij/kalmodulin-ovisna protein-kinaza ID je protein koji je kod ljudi kodiran genom CAMK1D na hromosomu 10 (lokus 10p13).^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca iznosi 385 aminokiselina, a molekularna masa 42.914.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MARENGESSS	SWKKQAEDIK	KIFEFKETLG	TGAFSEVVLA	EEKATGKLFA
VKCIPKKALK	GKESSIENEI	AVLRKIKHEN	IVALEDIYES	PNHLYLVMQL
VSGGELFDRI	VEKGFYTEKD	ASTLIRQVLD	AVYYLHRMGI	VHRDLKPENL
LYYSQDEESK	IMISDFGLSK	MEGKGDVMST	ACGTPGYVAP	EVLAQKPYSK
AVDCWSIGVI	AYILLCGYPP	FYDENDSKLF	EQILKAEYEF	DSPYWDDISD
SAKDFIRNLM	EKDPNKRYTC	EQAARHPWIA	GDTALNKNIH	ESVSAQIRKN
FAKSKWRQAF	NATAVVRHMR	KLHLGSSLDS	SNASVSSSLS	LASQKDCLAP
STLCSFISSS	SGVSGVGAER	RPRPTTVTAV	HSGSK

Funkcija

Ovaj gen kodira člana Ca2+/kalmodulin ovisne protein-kinaze 1 potporodice serin/treonin kinaza. Kodirani protein može biti uključen u regulaciju funkcije granulocita putem transdukcije signala hemokina. Opisane su alternativno prerađene varijante transkripta koje kodiraju različite izoforme ovog gena.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183049 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039145 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Calcium/calmodulin-dependent protein kinase ID".
^ "UniProt, Q8IU85". Pristupljeno 30. 8. 2021.

Vanjski linkovi

Lokacija ljudskog genoma CAMK1D i stranica sa detaljima o genu CAMK1D u UCSC Genome Browseru.
Q8IU85

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183049 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039145 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Calcium/calmodulin-dependent protein kinase ID".

[UniProt-6] "UniProt, Q8IU85". Pristupljeno 30. 8. 2021.

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