CD80 molecule (Q5009843)

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mammalian protein found in Homo sapiens

B7
BB1
CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
CD80
T-lymphocyte activation antigen CD80
costimulatory factor CD80
B-lymphocyte activation antigen B7
CTLA-4 counter-receptor B7.1
costimulatory molecule variant IgV-CD80
activation B7-1 antigen
B7-1 Antigen

Language	Label	Description	Also known as
English	CD80 molecule	mammalian protein found in Homo sapiens	B7 BB1 CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) CD80 T-lymphocyte activation antigen CD80 costimulatory factor CD80 B-lymphocyte activation antigen B7 CTLA-4 counter-receptor B7.1 costimulatory molecule variant IgV-CD80 activation B7-1 antigen B7-1 Antigen

Statements

1 reference

13 November 2019

UniProt protein ID

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin V-set domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CD80, IgC-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CD80-like, immunoglobulin C2-set, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

coreceptor activity

determination method or standard

1 reference

31 October 2017

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

virus receptor activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

protein binding

determination method or standard

6 references

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

8 April 2019

Structure and Interactions of the Human Programmed Cell Death 1 Receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

8 April 2019

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

8 April 2019

A secreted protein microarray platform for extracellular protein interaction discovery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

8 April 2019

PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

8 April 2019

Interaction of human PD-L1 and B7-1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

external side of plasma membrane

determination method or standard

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

protein complex involved in cell adhesion

determination method or standard

1 reference

8 April 2019

Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

external side of plasma membrane

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

determination method or standard

integral component of membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

biological process

intracellular signal transduction

determination method or standard

1 reference

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of alpha-beta T cell proliferation

determination method or standard

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

cell-cell signaling

determination method or standard

1 reference

31 October 2017

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of signal transduction

determination method or standard

1 reference

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

cellular response to lipopolysaccharide

determination method or standard

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of T-helper 1 cell differentiation

determination method or standard

1 reference

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

viral entry into host cell

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of T cell proliferation

determination method or standard

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of peptidyl-tyrosine phosphorylation

determination method or standard

1 reference

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

T cell activation

determination method or standard

1 reference

31 October 2017

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

phosphatidylinositol phosphate biosynthetic process

determination method or standard

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of protein kinase B signaling

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

immune response

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

cell surface receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

cytokine-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

T cell costimulation

determination method or standard

positive regulation of T cell proliferation

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

negative regulation of T cell proliferation

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

cellular response to lipopolysaccharide

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

physically interacts with

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201823

http://purl.uniprot.org/uniprot/P33681

1 reference

Identifiers.org

CD80-like, immunoglobulin C2-set

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

immunoglobulin V-set domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

immunoglobulin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

immunoglobulin subtype

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

CD80, IgC-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

Identifiers

MeSH descriptor ID

subject named as

B7-1 Antigen

0 references

D12.776.467.150.100

0 references

D12.776.543.095.100

0 references

D23.050.301.285.100

0 references

D23.529.168.100

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000264246

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000264246

ENSP00000373165

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373165

ENSP00000418364

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418364

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(13 entries)

arwiki كتلة التمايز 80
cswiki CD80
dewiki B7-1
enwiki CD80
eswiki CD80
fawiki CD80
plwiki CD80
ruwiki CD80
trwiki CD80
ttwiki CD80
ukwiki CD80
urwiki سیڈی اسی
zhwiki CD80

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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