The RUNX genes: gain or loss of function in cancer (Q28247901)

Solution structure of core binding factor beta and map of the CBF alpha binding site

Europe PubMed Central

title

The RUNX genes: gain or loss of function in cancer (English)

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1

Karen Blyth

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author name string

Ewan R Cameron

series ordinal

2

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James C Neil

series ordinal

3

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language of work or name

English

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publication date

May 2005

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published in

Nature Reviews Cancer

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volume

5

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issue

5

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page(s)

376-87

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cites work

1 reference

Conservation and expression of an alternative 3' exon of Runx2 encoding a novel proline-rich C-terminal domain

20 April 2017

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AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization

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Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation

20 April 2017

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

20 April 2017

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

20 April 2017

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Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

20 April 2017

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Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons

20 April 2017

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Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

20 April 2017

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The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor

20 April 2017

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Causal relationship between the loss of RUNX3 expression and gastric cancer

20 April 2017

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Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia

20 April 2017

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Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia

20 April 2017

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Core-binding factors in hematopoiesis and immune function

20 April 2017

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Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

20 April 2017

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A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

20 April 2017

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Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter

20 April 2017

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Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter

20 April 2017

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AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons

20 April 2017

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Regulation of chondrocyte differentiation by Cbfa1

20 April 2017

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Cbfbeta interacts with Runx2 and has a critical role in bone development

20 April 2017

1 reference

The core-binding factor beta subunit is required for bone formation and hematopoietic maturation

20 April 2017

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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

20 April 2017

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Nomenclature for Runt-related (RUNX) proteins

20 April 2017

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Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q.

21 January 2018

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Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors

21 January 2018

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Groucho-dependent and -independent repression activities of Runt domain proteins

21 January 2018

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Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

21 January 2018

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Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

21 January 2018

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Ftz modulates Runt-dependent activation and repression of segment-polarity gene transcription

21 January 2018

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Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation

21 January 2018

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The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability

21 January 2018

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Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms

21 January 2018

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AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.

21 January 2018

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Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways

21 January 2018

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The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.

21 January 2018

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Upstream and downstream targets of RUNX proteins.

21 January 2018

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

21 January 2018

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The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons

21 January 2018

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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

21 January 2018

1 reference

runt homology domain transcription factors (Runx, Cbfa, and AML) mediate repression of the bone sialoprotein promoter: evidence for promoter context-dependent activity of Cbfa proteins

21 January 2018

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The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region

21 January 2018

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21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop

21 January 2018

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The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

21 January 2018

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Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias

21 January 2018

1 reference

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

21 January 2018

1 reference

ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

21 January 2018

1 reference

The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

21 January 2018

1 reference

The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates

21 January 2018

1 reference

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

21 January 2018

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Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

21 January 2018

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Core-binding factors in haematopoiesis and leukaemia

21 January 2018

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The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

21 January 2018

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The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells

21 January 2018

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Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.

21 January 2018

1 reference

Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation

21 January 2018

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Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice

21 January 2018

1 reference

Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: a model for human AML

21 January 2018

1 reference

Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformation

21 January 2018

1 reference

High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia

21 January 2018

1 reference

In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis

21 January 2018

1 reference

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

21 January 2018

1 reference

Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers

21 January 2018

1 reference

Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma

21 January 2018

1 reference

Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines

21 January 2018

1 reference

Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer.

21 January 2018

1 reference

Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer.

21 January 2018

1 reference

RUNX transcription factors as key targets of TGF-beta superfamily signaling

21 January 2018

1 reference

Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor

21 January 2018

1 reference

RUNX3 inhibits cell proliferation and induces apoptosis by reinstating transforming growth factor beta responsiveness in esophageal adenocarcinoma cells

21 January 2018

1 reference

Origins of chromosome translocations in childhood leukaemia

21 January 2018

1 reference

AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency

21 January 2018

1 reference

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

21 January 2018

1 reference

Lineage specificity of CBFA2 fusion transcripts

21 January 2018

1 reference

The t(8;21) fusion protein, AML1/ETO, transforms NIH3T3 cells and activates AP-1.

21 January 2018

1 reference

TEL/AML1 shows dominant-negative effects over TEL as well as AML1.

21 January 2018

1 reference

The AML1/ETO fusion protein activates transcription of BCL-2

21 January 2018

1 reference

E protein silencing by the leukemogenic AML1-ETO fusion protein

21 January 2018

1 reference

Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

21 January 2018

1 reference

Chromosome translocations and covert leukemic clones are generated during normal fetal development

21 January 2018

1 reference

An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice

21 January 2018

1 reference

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

21 January 2018

1 reference

Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1

21 January 2018

1 reference

Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene

21 January 2018

1 reference

Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia

21 January 2018

1 reference

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer

21 January 2018

1 reference

Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas

21 January 2018

1 reference

Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice

21 January 2018

1 reference

The common retroviral insertion locus Dsi1 maps 30 kilobases upstream of the P1 promoter of the murine Runx3/Cbfa3/Aml2 gene

21 January 2018

1 reference

Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases.

21 January 2018

1 reference

New mechanisms of AML1 gene alteration in hematological malignancies

21 January 2018

1 reference

Risks of leukaemia and solid tumours in individuals with Down's syndrome.

21 January 2018

1 reference

Chromosome 21 abnormalities with AML1 amplification in acute lymphoblastic leukemia

21 January 2018

1 reference

AML1 gene over-expression in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53.

21 January 2018

1 reference

The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia

21 January 2018

1 reference

Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes

21 January 2018

1 reference

Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle

21 January 2018

1 reference

AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression

21 January 2018

1 reference

Frequent amplification and rearrangement of chromosomal bands 6p12-p21 and 17p11.2 in osteosarcoma

21 January 2018

1 reference

Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2.

21 January 2018

1 reference

Regulation of TGFbeta1-mediated growth inhibition and apoptosis by RUNX2 isoforms in endothelial cells

21 January 2018

1 reference

Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling

21 January 2018

1 reference

Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2.

21 January 2018

1 reference

Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway

21 January 2018

1 reference

The osteoblast transcription factor Runx2 is expressed in mammary epithelial cells and mediates osteopontin expression.

21 January 2018

1 reference

Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation

21 January 2018

1 reference

Smad3 interacts with JunB and Cbfa1/Runx2 for transforming growth factor-beta1-stimulated collagenase-3 expression in human breast cancer cells

21 January 2018

1 reference

Regulation of human osteocalcin promoter in hormone-independent human prostate cancer cells

21 January 2018

1 reference

RUNX3 expression in primary and metastatic pancreatic cancer

21 January 2018

1 reference

Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes

21 January 2018

1 reference

Genome‐wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation‐mediated fusion events

21 January 2018

1 reference

Expression of transcription factor AML-2 (RUNX3, CBF(alpha)-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype

21 January 2018

1 reference

Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells.

21 January 2018

1 reference

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

21 January 2018

1 reference

Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.

21 January 2018

1 reference

Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein

21 January 2018

1 reference

Inhibition of the transforming growth factor beta 1 signaling pathway by the AML1/ETO leukemia-associated fusion protein

21 January 2018

1 reference

Maturational disturbance of chondrocytes in Cbfa1-deficient mice

21 January 2018

1 reference

Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation

21 January 2018

1 reference

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

21 January 2018

1 reference

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

21 January 2018

1 reference

Core-binding factor beta interacts with Runx2 and is required for skeletal development

21 January 2018

1 reference

Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome

21 January 2018

1 reference

Isolation of the Drosophila segmentation gene runt and analysis of its expression during embryogenesis.

21 January 2018

1 reference

Alternative splicing and genomic structure of theAML1gene involved in acute myeloid leukemia

31 March 2020

1 reference

A large variety of alternatively spliced and differentially expressed mRNAs are encoded by the human acute myeloid leukemia gene AML1.

31 March 2020

1 reference

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

31 March 2020

1 reference

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

31 March 2020

1 reference

Correlation between the ETV6/CBFA2 (TEL/AML1) fusion gene and karyotypic abnormalities in children with B-cell precursor acute lymphoblastic leukemia

31 March 2020

1 reference

TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity

31 March 2020

1 reference

Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia

31 March 2020

1 reference

AML-1 mutations outside the RUNT domain: description of two cases in myeloid malignancies

31 March 2020

1 reference

Unanswered Questions about the Role of Promoter Methylation in Carcinogenesis

31 March 2020

1 reference

Prenatal origin of acute lymphoblastic leukaemia in children

31 March 2020

1 reference

TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia

31 March 2020

1 reference

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

31 March 2020

1 reference

til-1: a novel proviral insertion locus for Moloney murine leukaemia virus in lymphomas of CD2-myc transgenic mice

31 March 2020

1 reference

New genes involved in cancer identified by retroviral tagging

31 March 2020

1 reference

High-throughput retroviral tagging for identification of genes involved in initiation and progression of mouse splenic marginal zone lymphomas.

31 March 2020

1 reference

An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms.

31 March 2020

1 reference

A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc

31 March 2020

1 reference

Leukemia in Down syndrome: a review

31 March 2020

1 reference

Amplification of AML1 gene is present in childhood acute lymphoblastic leukemia but not in adult, and is not associated with AML1 gene mutation

31 March 2020

1 reference

Expression of myeloid-specific genes in childhood acute lymphoblastic leukemia - a cDNA array study

31 March 2020

1 reference

A differential gene expression profile reveals overexpression of RUNX1/AML1 in invasive endometrioid carcinoma.

31 March 2020

1 reference

Comparative genomic hybridization analysis of human sarcomas: II. Identification of novel amplicons at 6p and 17p in osteosarcomas

31 March 2020

1 reference

Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selection

31 March 2020

1 reference

Runx2: a novel oncogenic effector revealed by in vivo complementation and retroviral tagging

31 March 2020

1 reference

The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2

31 March 2020

1 reference

Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease.

31 March 2020

1 reference

Prostate cancer expression of runt‐domain transcription factor Runx2, a key regulator of osteoblast differentiation and function

31 March 2020

1 reference

Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo

31 March 2020

1 reference

Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors

31 March 2020

1 reference

Potential role of cbfa1, an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis: regulation of mRNA expression of osteoclast differentiation factor (ODF)

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1607

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1016913969

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Fatcat ID

release_fec2vseusrcsbprjqovupm2xzi

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Fatcat

https://api.fatcat.wiki/v0/release/fec2vseusrcsbprjqovupm2xzi

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

15864279

1 reference

Consolidated OpenCitations Corpus – April 2017