Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

Regulating MYC translation in cancer

Nature Cell Biology (2025)Cite this article

Subjects

Layered control of oncogenic protein dosage enables the hallmarks of cancer, but specific regulators of oncogene mRNA translation remain unknown. A study now reports RMB42 as a regulator of the MYC by remodelling its RNA structure and increasing translation efficiency, highlighting a potential therapeutic avenue to target MYC-driven cancers.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: RBM42 is a RBP and RAP that facilitates MYC translation.

References

  1. Dhanasekaran, R. et al. Nat. Rev. Clin. Oncol. 19, 23–36 (2022).

    Article  CAS  PubMed  Google Scholar 

  2. Hayashi, A., Hong, J. & Iacobuzio-Donahue, C. A. Nat. Rev. Gastroenterol. Hepatol. 18, 469–481 (2021).

    Article  PubMed  Google Scholar 

  3. Chen, H., Liu, H. & Qing, G. Signal Transduct. Target. Ther. 3, 1–7 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Kovalski, J. R. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01604-7 (2025).

    Article  Google Scholar 

  5. Hentze, M. W., Castello, A., Schwarzl, T. & Preiss, T. Nat. Rev. Mol. Cell Biol. 19, 327–341 (2018).

    Article  CAS  PubMed  Google Scholar 

  6. Maddipati, R. et al. Cancer Discov. 12, 542–561 (2022).

    Article  CAS  PubMed  Google Scholar 

  7. Sears, R. et al. Genes Dev. 14, 2501–2514 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Bhattacharyya, S. et al. J. Exp. Med. 217, (2020).

  9. George, J. et al. Cell Rep. 37, 109934 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Mukherjee, M. & Goswami, S. Front. Cell Dev. Biol. 9, 1–17 (2021).

    Article  Google Scholar 

  11. Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M. & Maitra, A. Cell 186, 1729–1754 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Dilly, J. et al. Cancer Discov. 14, 2135–2161 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Wasko, U. N. et al. Nature 629, 927–936 (2024).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Li, J., Dong, T., Wu, Z., Zhu, D. & Gu, H. Cell Death Discov. 9, 1–10 (2023).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Zainab Hussain & Mara H. Sherman

Authors
  1. Zainab Hussain
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mara H. Sherman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mara H. Sherman.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hussain, Z., Sherman, M.H. Regulating MYC translation in cancer. Nat Cell Biol (2025). https://doi.org/10.1038/s41556-024-01589-3

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41556-024-01589-3

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer