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Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.
By suppressing compositional heterogeneities in cadmium-free quantum dots, environmentally friendly pure-blue-light-emitting diodes with enhanced efficiencies, lifetimes and spectral purity are achieved, rivalling state-of-the-art cadmium-based blue quantum-dot light-emitting diodes.
Analysis of gravitational waves from merging binary neutron stars was accelerated using machine learning, enabling full low-latency parameter estimation and enhancing the potential for multi-messenger observations.
cAMP produced by the TIR1/AFB receptors of the main endogenous developmental plant hormone auxin acts as a true second messenger, revising the established paradigm of transcriptional auxin signalling.
Bone tools shaped by knapping found within Olduvai Gorge in Tanzania precede any other evidence of systematic bone tool production by more than 1 million years.
Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and catastrophic cell division.
Pattern-based detection and attribution methods that make use of trend pattern information as a function of month and height provide evidence that reduction of ozone-depleting substances has resulted in the beginning of Antarctic ozone recovery.
Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell types with key roles in physiological and social behaviour functions have been identified.
Computational drug discovery is used to identify a 12-mer peptide derived from BRINP2 with potent anti-obesity effects that are independent of leptin, glucagon-like peptide 1 receptor and melanocortin 4 receptor.
Construction of a phosphate passivation layer on the surface of a cathode to withstand fluctuating operation in alkaline seawater is proposed following understanding the mechanism behind the dynamic evolution and degradation of cathode in intermittent electrolysis.
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that could lead to biotechnology applications and therapeutic interventions.
A mixed-precision heterogeneous memristor combined with a compute-in-memory artificial intelligence (AI) processor allows optimization of the precision, energy efficiency, storage and wakeup-to-response time requirements of AI edge devices, which is demonstrated using existing models and datasets.
Structural findings define the architecture of the mitochondrial pyruvate carrier, delineate its substrate-binding site and translocation pathway, and reveal its major conformational states, providing the molecular basis for understanding its function and inhibition.
Behavioural experiments in mice demonstrate that GABAergic (γ-aminobutyric acid-expressing), glutamatergic and serotonergic neurons in the median raphe nucleus have distinct and complementary functions in regulating decision-making resulting in flexible behavioural strategies.
A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance, potentially revolutionizing chronic pain treatment and GPCR drug design.
Reversed precipitation responses to Amazon deforestation show that deforestation leads to precipitation increases in the wet season and decreases in the dry season.
In the Multicellularity Long Term Evolution Experiment, diploid yeast evolve to be tetraploid under selection for larger multicellular size, revealing how whole-genome duplication can arise due to its immediate benefits, persist under selection, and fuel long-term innovations via aneuploidy.
