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Phil S. Baran

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Phil S. Baran
BornAugust 10, 1977 (1977-08-10) (age 47)
Denville, NJ
NationalityAmerican
Alma materLake Sumter Community College (AA, 1995)
New York University (BS, 1997)
Scripps Research Institute (PhD, 2001)
Scientific career
FieldsChemistry
InstitutionsSkaggs Institute for Chemical Biology

Phil S. Baran (born August 10, 1977) is a synthetic organic chemist and Professor in the Department of Chemistry at the Scripps Research Institute.[1] His work is focused on synthesizing complex natural products,[2] the development of new reaction methodologies within synthetic organic electrochemistry,[3] and the development of new reagents.[4] He holds several patents and has authored nearly 300 research articles.

Early life and education

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Phil S. Baran was born in Denville, New Jersey, on August 10, 1977, and grew up in Coral Springs, Florida, where his family moved to help ease his brothers’ asthma. He remembers being a poor student at high school, preferring to play role-playing games, write computer programs and build with Lego.[5]

Encouraged by his chemistry teacher to experiment after school, Baran quickly channeled his creativity into crafting molecules. In 1995 he began a chemistry degree at New York University, and enthusiastically accepted [David] Schuster’s offer to work in his lab, synthesizing compounds that linked C60 with porphyrins to make artificial photosynthetic systems.[5] He received his BS in chemistry from New York University in 1997.

He went on to earn his PhD from The Scripps Research Institute in 2001, under the supervision of K. C. Nicolaou, an experience he recalls was 'like hardcore Navy Seal training'[5] and where he co-authored 30 papers in less than four years.

He then moved to do a postdoctoral fellowship in the laboratory of Nobel Laureate Elias James Corey at Harvard University who reflected Baran's time in his lab, saying that, "He had a phenomenal grasp of synthetic chemistry," and "felt that he could be a leader in his generation."[5]

Independent career

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Total syntheses

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  • Dragocins A−C (2024)[1]
  • Dynobactin A (2024)
  • (−)-Cyclopamine (2023)
  • (+)-KB343 (2023)
  • Portimine A and B (2023)
  • Kibdelomycin (2022)
  • Darobactin A (2022)
  • (+)-Calcipotriol (2022)
  • Tagetitoxin (2020)
  • (–)-Maximiscin (2020)
  • Taxol (2020)
  • Teleocidins B-1-B-4 (2019)
  • Herqulines B and C (2019)
  • (–)-Thapsigargin (2017)
  • Ariaosamines (2016)
  • (–)-Maoecrystal V (2016)
  • Pallambins C and D (2016)
  • (+)-Phorbol (2016)
  • Verruculogen (2015)
  • Fumitremorgin A (2015)
  • Ouabagenin (2013, 2015)
  • Dixiamycin B (2014)
  • (+)-Ingenol (2014)
  • (–)-Taxuyunnanine (2014)
  • (+)-Hongoquercin A (2013)
  • Phellodonin (2013)
  • Sarcodonin (2013)
  • Pipercyclobutanamide A (2012)
  • (+)-Taxadienone (2011)
  • (+)-Psychotetramine (2011)
  • (–)-Palau’amine (2010)
  • Vinigrol (2009)
  • (±)-Massadine (2008)
  • (±)-Psychotrimine (2008)
  • Cortistatin A (2008)
  • (–)-Axinellamine A and B (2008)
  • (±)-Chartelline C (2006)
  • Haouamine A (2006)
  • Avrainvillamide (2005)
  • Stephacidin A (2005)
  • (S)-Ketorolac (2005)
  • Sceptrin (2004)

Publications

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Phil S. Baran has authored nearly 300 research publications and has an h-index of 126 with over 50,000 citations.[6]

He co-wrote the digital interactive reference text The Portable Chemist’s Consultant: A Survival Guide for Discovery, Process, and Radiolabeling as well as several book chapters and forewords.[7][8][9][10][11][12][13][14][15]

Awards and honors

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  • Highly Cited Researcher (2020)[16]
  • Emanuel Merck Lectureship, 2017[17]
  • Mukaiyama Award, 2014
  • MacArthur Fellowship, 2013
  • Royal Society of Chemistry Synthetic Organic Chemistry Award, 2013
  • ACS San Diego Section Distinguished Scientist Award, 2012
  • ISHC Katritzky Heterocyclic Chemistry Award, 2011
  • Thieme–IUPAC Prize in Synthetic Organic Chemistry, 2010
  • ACS Award in Pure Chemistry, 2010
  • Sackler Prize, 2009
  • Novartis Lecturer, 2007–2008
  • Hirata Gold Medal, 2007
  • National Fresenius Award, 2007
  • Pfizer Award for Creativity in Organic Chemistry, 2006
  • Beckman Young Investigators Award, 2006[18]
  • Alfred P. Sloan Foundation Fellow, 2006–2008
  • BMS Unrestricted "Freedom to Discover" Grant, 2006–2010
  • NSF Career, 2006–2010
  • Eli-Lilly Young Investigator Award, 2005–2006
  • AstraZeneca Excellence in Chemistry Award, 2005
  • DuPont Young Professor Award, 2005
  • Roche Excellence in Chemistry Award, 2005
  • Amgen Young Investigator Award, 2005
  • Searle Scholar Award, 2005
  • GlaxoSmithKline Chemistry Scholar Award, 2005–2006
  • Nobel Laureate Signature Award for Graduate Education in Chemistry, ACS, 2003
  • National Institutes of Health Post-Doctoral Fellowship Award, Harvard, 2001–2003
  • Hoffmann-La Roche Award for Excellence in Organic Chemistry, 2000
  • Lesly Starr Shelton Award for Excellence in Chemistry Graduate Studies, 2000
  • National Science Foundation Pre-Doctoral Fellowship Award, Scripps, 1998–2001

References

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  1. ^ The Baran Laboratory Archived June 6, 2017, at the Wayback Machine, Scripps Research Institute
  2. ^ "Baran Lab". Retrieved August 27, 2023.
  3. ^ "Phil S. Baran" (PDF). Retrieved August 27, 2023.
  4. ^ "Baran Group – Professor Product Portal". Sigma-Aldrich.
  5. ^ a b c d Peplow, Mark (2014). "The sultan of synthesis". Features. Chemistry World. Vol. 11. Royal Society of Chemistry. ISSN 1473-7604. OCLC 5585253041. Retrieved November 12, 2024.
  6. ^ "Phil Baran". scholar.google.com. Retrieved November 12, 2024.
  7. ^ Gianatassio, Ryan; Ishihara, Yoshihiro; Baran, Phil S. (October 20, 2014), "Sodium 1,1-Difluoroethanesulfinate", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–2, doi:10.1002/047084289x.rn01783, ISBN 978-0-470-84289-8, retrieved November 12, 2024
  8. ^ Gianatassio, Ryan; Ishihara, Yoshihiro; Baran, Phil S. (October 20, 2014), "Zinc Difluoromethanesulfinate", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–3, doi:10.1002/047084289x.rn01787, ISBN 978-0-470-84289-8, retrieved November 12, 2024
  9. ^ Gianatassio, Ryan; Ishihara, Yoshihiro; Baran, Phil S. (October 20, 2014), "Zinc Difluoromethanesulfinate", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–3, doi:10.1002/047084289x.rn01787, ISBN 978-0-470-84289-8, retrieved November 12, 2024
  10. ^ Ishihara, Yoshihiro; Gianatassio, Ryan; Baran, Phil S. (October 20, 2014), "Zinc Isopropylsulfinate", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–3, doi:10.1002/047084289x.rn01785, ISBN 978-0-470-84289-8, retrieved November 12, 2024
  11. ^ Ishihara, Yoshihiro; Gianatassio, Ryan; Baran, Phil S. (October 20, 2014), "Zinc Trifluoromethanesulfinate", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–3, doi:10.1002/047084289x.rn01786, ISBN 978-0-470-84289-8, retrieved November 12, 2024
  12. ^ Pan, Chung-Mao; Ishihara, Yoshihiro; Baran, Phil S. (March 31, 2016), "Palau'chlor", Encyclopedia of Reagents for Organic Synthesis, Chichester, UK: John Wiley & Sons, Ltd, pp. 1–2, doi:10.1002/047084289x.rn01901, ISBN 978-0-470-84289-8, retrieved November 12, 2024
  13. ^ Li, Jie Jack; Limberakis, Chris; Pflum, Derek A. (January 10, 2008). Modern Organic Synthesis in the Laboratory. Oxford University Press. ISBN 978-0-19-518798-4.
  14. ^ Li, Jie Jack (September 28, 2006), "Cardiovascular Drugs: From Nitroglycerin to Lipitor", Laughing Gas, Viagra, and Lipitor, Oxford University Press, ISBN 978-0-19-530099-4, retrieved November 12, 2024
  15. ^ Li, Jie Jack, ed. (March 30, 2009). Name Reactions for Homologations, Part I. Hoboken, NJ, USA: John Wiley & Sons, Inc. ISBN 978-0-470-48702-0.
  16. ^ "Scripps Research scientists capture 15 spots on ranking of most highly cited researchers". www.scripps.edu. Retrieved August 27, 2023.
  17. ^ Merck Group
  18. ^ "Phil S. Baran". Arnold and Mabel Beckman Foundation. Archived from the original on August 2, 2018. Retrieved August 1, 2018.
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