NCAPD2

NCAPD2
Identifiers
Aliases	NCAPD2, CAP-D2, CNAP1, hCAP-D2, non-SMC condensin I complex subunit D2, MCPH21
External IDs	OMIM: 615638; MGI: 1915548; HomoloGene: 6497; GeneCards: NCAPD2; OMA:NCAPD2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,531,955 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	125,168,664 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; bone marrow cells; ; stromal cell of endometrium; ; granulocyte; ; rectum; ; epithelium of colon; ; gonad; ; Descending thoracic aorta; ; gastric mucosa;
	Top expressed in
	tail of embryo; ; ventricular zone; ; genital tubercle; ; mandibular prominence; ; yolk sac; ; maxillary prominence; ; thymus; ; spermatocyte; ; epiblast; ; somite;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone binding; chromatin binding; protein binding;
Cellular component	cytoplasm; membrane; chromosome; nucleoplasm; condensin complex; nuclear chromosome; condensed chromosome; nucleus; condensed chromosome, centromeric region; cytosol;
Biological process	mitotic chromosome condensation; meiotic chromosome condensation; cell division; chromosome separation; chromosome condensation; cell cycle; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	9918
	68298
	ENSG00000010292
	ENSMUSG00000038252
	Q15021
	Q8K2Z4
	NM_014865
	NM_146171
	NP_055680
	NP_666283
	Wikidata
View/Edit Human	View/Edit Mouse

Condensin complex subunit 1 also known as chromosome-associated protein D2 (CAP-D2) or non-SMC condensin I complex subunit D2 (NCAPD2) or XCAP-D2 homolog is a protein that in humans is encoded by the NCAPD2 gene.^[5]^[6]^[7] CAP-D2 is a subunit of condensin I, a large protein complex involved in chromosome condensation.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000010292 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038252 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. CiteSeerX 10.1.1.333.6945. doi:10.1093/dnares/2.4.167. PMID 8590280.
^ Schmiesing JA, Gregson HC, Zhou S, Yokomori K (Sep 2000). "A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation". Mol Cell Biol. 20 (18): 6996–7006. doi:10.1128/MCB.20.18.6996-7006.2000. PMC 88774. PMID 10958694.
^ "Entrez Gene: NCAPD2 non-SMC condensin I complex, subunit D2".

Simon MA (1999). "Racial, ethnic, and gender diversity and the resident operative experience. How can the Academic Orthopaedic Society shape the future of orthopaedic surgery?". Clin. Orthop. Relat. Res. 360 (360): 253–9. doi:10.1097/00003086-199903000-00031. PMID 10101332.
Collas P, Le Guellec K, Taskén K (2000). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis". J. Cell Biol. 147 (6): 1167–80. doi:10.1083/jcb.147.6.1167. PMC 2168084. PMID 10601332.
Kimura K, Cuvier O, Hirano T (2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts". J. Biol. Chem. 276 (8): 5417–20. doi:10.1074/jbc.C000873200. PMID 11136719.
Ball AR, Schmiesing JA, Zhou C, et al. (2002). "Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7". Mol. Cell. Biol. 22 (16): 5769–81. doi:10.1128/MCB.22.16.5769-5781.2002. PMC 133980. PMID 12138188.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000010292 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038252 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8590280-5] Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. CiteSeerX 10.1.1.333.6945. doi:10.1093/dnares/2.4.167. PMID 8590280.

[pmid10958694-6] Schmiesing JA, Gregson HC, Zhou S, Yokomori K (Sep 2000). "A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation". Mol Cell Biol. 20 (18): 6996–7006. doi:10.1128/MCB.20.18.6996-7006.2000. PMC 88774. PMID 10958694.

[entrez-7] "Entrez Gene: NCAPD2 non-SMC condensin I complex, subunit D2".

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References

Further reading