Talk:Flumazenil

Anxiety

This stuff probably causes brutal anxiety in many people. Benzo withdrawal itself causes nightmarish anxiety, with episodes of panic, which can persist for months. I suspect Flumazenil would make it worse in many cases. A benzo-induced coma is not a good thing, certainly. Waking up from a coma into an all-out panic attack would be really bad, and would present patient management problems of its own.

Years ago, I read of some kind of benzo antagonist being used by Soviet authorities on political dissidents, in psychiatric hospitals, as a torture method. Ugly.

There's plenty of medical evidence for this problem. Just google "Flumazenil (anxiety OR panic)" without the quotes.

This article should mention some of these issues. 69.110.107.45 (talk) 00:50, 11 October 2013 (UTC)

A benzo antagonist like flumazenil has no effect on healthy individuals because no chemicals in the body naturally bind to the benzodiazepine site. 94.195.135.88 (talk) 06:50, 31 August 2016 (UTC)

I find it interesting that we call this drug an antagonist of the benzodiazepine receptor, and yet we do not get withdrawal symptoms when it is administered to dependent patients. I suspect this drug is actually an extremely "close to normal function" partial agonist? Can someone clarify this for me please? — Preceding unsigned comment added by 121.44.197.228 (talk) 23:20, 14 June 2019 (UTC)

Silent Allosteric Modulator

This page states (in the introduction) that Flumazenil is an antagonist of the GABAa receptor. This is technically incorrect. An antagonist of the GABAa receptor would prevent GABA from activating the receptor, while Flumazenil has no effect on GABA binding or activity.

I think the most accurate classification for Flumazenil is a silent allosteric modulator of the GABAa receptor, as it only affects the binding of compounds to the BZD site without affecting activity otherwise. — Preceding unsigned comment added by 141.214.17.201 (talk) 20:57, 13 October 2013 (UTC)

IUPAC Name

Hey, shouldn't the IUPAC name be Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate? --PolynomialHelix (talk) 02:42, 4 November 2014 (UTC)

There should be a link to the "Downregulation and upregulation"

The article would be better understood if the reader was provided a link that explains what up and down regulation mean. — Preceding unsigned comment added by 172.78.76.206 (talk) 02:42, 27 April 2016 (UTC)

External links modified

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Possible sneaky vandalism

Hi!

I suspect that this edit might be a sneaky bit of vandalism. What are your thoughts? Is otic flumazenil administration really a thing?

Regards, TealHill (talk) 07:28, 21 July 2020 (UTC)