Neuromedin S is a 36-amino acid neuropeptide found in the brain of humans and other mammals. It is produced in the suprachiasmatic nucleus of the hypothalamus and is related to neuromedin U. It is thought to be involved in regulation of circadian rhythm and also has appetite suppressant effects,[1][2][3][4][5] as well as regulating the release of several other peptide hormones including vasopressin,[6] luteinizing hormone,[7] and oxytocin.[8]
| Neuromedin S | |
|---|---|
| Identifiers | |
| Symbol | NMS |
| NCBI gene | 129521 |
| HGNC | 32203 |
| Other data | |
| Locus | Chr. 2 q11.2 |
See also
editReferences
edit- ^ Mori K, Miyazato M, Ida T, Murakami N, Serino R, Ueta Y, Kojima M, Kangawa K (January 2005). "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system". The EMBO Journal. 24 (2): 325–35. doi:10.1038/sj.emboj.7600526. PMC 545815. PMID 15635449.
- ^ Mori K, Miyazato M, Kangawa K (2008). "Neuromedin S: Discovery and Functions". Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation. Vol. 46. pp. 201–12. doi:10.1007/400_2007_054. ISBN 978-3-540-78350-3. PMID 18214396.
- ^ Novak CM (July 2009). "Neuromedin S and U". Endocrinology. 150 (7): 2985–7. doi:10.1210/en.2009-0448. PMC 2703548. PMID 19549882.
- ^ Peier A, Kosinski J, Cox-York K, Qian Y, Desai K, Feng Y, Trivedi P, Hastings N, Marsh DJ (July 2009). "The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2)". Endocrinology. 150 (7): 3101–9. doi:10.1210/en.2008-1772. PMC 2703546. PMID 19324999.
- ^ Mitchell J, Maguire J, Davenport A (June 2009). "Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S". British Journal of Pharmacology. 158 (1): 87–103. doi:10.1111/j.1476-5381.2009.00252.x. PMC 2795236. PMID 19519756.
- ^ Sakamoto T, Mori K, Nakahara K, Miyazato M, Kangawa K, Sameshima H, Murakami N (September 2007). "Neuromedin S exerts an antidiuretic action in rats". Biochemical and Biophysical Research Communications. 361 (2): 457–61. doi:10.1016/j.bbrc.2007.07.036. PMID 17645872.
- ^ Vigo E, Roa J, López M, Castellano JM, Fernandez-Fernandez R, Navarro VM, Pineda R, Aguilar E, Diéguez C, Pinilla L, Tena-Sempere M (February 2007). "Neuromedin s as novel putative regulator of luteinizing hormone secretion". Endocrinology. 148 (2): 813–23. doi:10.1210/en.2006-0636. PMID 17110433.
- ^ Sakamoto T, Mori K, Miyazato M, Kangawa K, Sameshima H, Nakahara K, Murakami N (October 2008). "Involvement of neuromedin S in the oxytocin release response to suckling stimulus". Biochemical and Biophysical Research Communications. 375 (1): 49–53. doi:10.1016/j.bbrc.2008.07.124. PMID 18675786.