40S ribosomal protein S18

40S ribosomal protein S18 is a protein that in humans is encoded by the RPS18 gene.

RPS18
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS18, D6S218E, HKE3, KE-3, KE3, S18, ribosomal protein S18
External IDs	OMIM: 180473; MGI: 98146; HomoloGene: 88764; GeneCards: RPS18; OMA:RPS18 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.32 Start 33,272,075 bp End 33,276,511 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 17.98 cM Start 34,170,973 bp End 34,174,975 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary skin of leg skin of abdomen canal of the cervix lymph node ectocervix uterine tube lactiferous gland vagina Top expressed in ventricular zone lip blastocyst yolk sac morula neural layer of retina right kidney tail of embryo genital tubercle granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function rRNA binding protein binding nucleic acid binding RNA binding structural constituent of ribosome protein kinase binding Cellular component cytoplasm ribosome membrane focal adhesion intracellular anatomical structure small ribosomal subunit extracellular exosome nucleus nucleoplasm extracellular matrix cytosol cytosolic small ribosomal subunit postsynaptic density synapse Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis ribosome biogenesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6222 20084 Ensembl ENSG00000226225 ENSG00000096150 ENSG00000231500 ENSG00000235650 ENSG00000223367 ENSG00000227794 ENSMUSG00000008668 UniProt P62269 P62270 RefSeq (mRNA) NM_022551 NM_011296 NM_138946 RefSeq (protein) NP_072045 NP_035426 Location (UCSC) Chr 6: 33.27 – 33.28 Mb Chr 17: 34.17 – 34.17 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Chan YL, Paz V, Wool IG (1991). "The primary structure of rat ribosomal protein S18". Biochem. Biophys. Res. Commun. 178 (3): 1212–8. doi:10.1016/0006-291X(91)91022-5. PMC 335161. PMID 1872840.
• Chassin D, Bénifla JL, Delattre C, et al. (1994). "Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts". Cancer Res. 54 (19): 5217–23. PMID 7923143.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Mishra-Gorur K, Singer HA, Castellot JJ (2002). "The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II". J. Biol. Chem. 277 (37): 33537–40. doi:10.1074/jbc.C200342200. PMID 12145273.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Kusui K, Sasaki H, Adachi R, et al. (2005). "Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library". Mol. Cell. Biochem. 262 (1–2): 187–93. doi:10.1023/B:MCBI.0000038234.35936.1c. PMID 15532723. S2CID 30534195.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.

External links

• Overview of all the structural information available in the PDB for UniProt: P62269 (40S ribosomal protein S18) at the PDBe-KB.