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Apolipoprotein A-II

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(Redirected from APOA2)

APOA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPOA2, Apo-AII, ApoA-II, apoAII, Apolipoprotein A2
External IDsOMIM: 107670; MGI: 88050; HomoloGene: 1242; GeneCards: APOA2; OMA:APOA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001643

NM_013474
NM_001305549
NM_001305550
NM_001305585

RefSeq (protein)

NP_001634

NP_001292478
NP_001292479
NP_001292514
NP_038502

Location (UCSC)Chr 1: 161.22 – 161.22 MbChr 1: 171.05 – 171.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
ApoA-II
structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions
Identifiers
SymbolApoA-II
PfamPF04711
InterProIPR006801
SCOP21l6k / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene.[5] It is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear. [6] Remarkably, defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.[7]

Interactions

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ApoA-II has been shown to interact with phospholipid transfer protein.[8]

Interactive pathway map

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Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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Statin_Pathway_WP430go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|alt=Statin pathway edit]]
Statin pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158874Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005681Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tsao YK, Wei CF, Robberson DL, Gotto AM, Chan L (Dec 1985). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". The Journal of Biological Chemistry. 260 (28): 15222–31. doi:10.1016/S0021-9258(18)95725-X. PMID 2415515.
  6. ^ Tailleux A, Duriez P, Fruchart JC, Clavey V (September 2002). "Apolipoprotein A-II, HDL metabolism and atherosclerosis". Atherosclerosis. 164 (1): 1–13. doi:10.1016/s0021-9150(01)00751-1. ISSN 0021-9150. PMID 12119188.
  7. ^ "Entrez Gene: APOA2 apolipoprotein A-II".
  8. ^ Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". Journal of Lipid Research. 39 (1): 152–61. doi:10.1016/S0022-2275(20)34211-5. PMID 9469594.
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Further reading

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