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Association of hematological parameters with metabolic syndrome in Beijing adult population: a longitudinal study

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Abstract

The purposes of the study were to estimate the incidence of metabolic syndrome (MetS) and to systematically evaluate the relationship between hematological parameters and MetS in a 5-year follow-up of Beijing adult population. The longitudinal study included 3,180 adults, aged 20–65 years, who attended health check-ups in Beijing Tongren Hospital in 2007 and 2012. Multivariate logistic regression was conducted to explore the associations between hematological parameters and MetS. The 5-year cumulative incidence of MetS in this sample was 10.82 % (14.22 % for males and 7.59 % for females). Among all the hematological parameters, white blood cell count (WBC) was positively associated with MetS for 20–35-year-old (male OR 1.482, 95 % CI 1.169–2.974; female OR 1.398, 95 % CI 1.145–3.011), and 36–50-year-old (male OR 2.012, 95 % CI 1.290–4.010; female OR 3.400, 95 % CI 1.818–4.528) male and female subjects. Alanine aminotransferase (ALT) was significantly associated with the incidence of MetS for males (20–35-year-old OR 2.080, 95 % CI 1.371–3.159; 36–50-year-old OR 2.421, 95 % CI 1.335–3.412; 51–65-year-old OR 4.267, 95 % CI 1.161–6.781). Low-density lipoprotein cholesterol (LDL-C) was positively associated with MetS for 51–65-year-old (male OR 3.078, 95 % CI 2.468–5.131; female OR 2.140, 95 % CI 1.524–4.359) for male and female subjects. WBC is positively associated with MetS for young adults, while LDL-C is positively associated with MetS for elderly people. ALT is positively associated with MetS for males. Our findings provide further evidence in support of using hematological markers for early detection of individuals at risk for MetS.

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Acknowledgments

The study has been funded by the Major Project of Natural Science Fund of Beijing (Serial Number: 7131002); Key Projects in the National Science & Technology Pillar Program in the Twelfth Five-year Plan Period of China (2011BAI08B01); the Program of Natural Science Fund of China (Serial Number: 81373099). We also would like to thank the medical personnel who participated in data collection in the physical check-up department of Beijing TongRen Hospital.

Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. School of Public Health, Capital Medical University, 10 Xitoutiao, Youanmenwai, Fengtai, Beijing, 100069, China

    Li-Xin Tao, Xia Li, Hui-Ping Zhu, Tao Zhou, Lei Pan, Yan-Xia Luo, Wei Wang, Li-Juan Wu & Xiu-Hua Guo

  2. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China

    Li-Xin Tao, Xia Li, Hui-Ping Zhu, Tao Zhou, Lei Pan, Yan-Xia Luo, Wei Wang, Li-Juan Wu & Xiu-Hua Guo

  3. Department of Epidemiology & Public Health, University College Cork, Cork, 78746, Ireland

    Xia Li

  4. Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, 100013, China

    Da Huo

  5. School of Medical Science, Edith Cowan University, Mt Lawley, WA, 6050, Australia

    Wei Wang

  6. Department of Physical Examination, Beijing Tongren Hospital, Beijing, 100041, China

    Zhao-Ping Wang & Dong-Ning Chen

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  1. Li-Xin Tao
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Correspondence to Xiu-Hua Guo.

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Tao, LX., Li, X., Zhu, HP. et al. Association of hematological parameters with metabolic syndrome in Beijing adult population: a longitudinal study. Endocrine 46, 485–495 (2014). https://doi.org/10.1007/s12020-013-0067-z

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