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The location of the polio genome protein in viral RNAs and its implication for RNA synthesis

Nature volume 268, pages 208–213 (1977)Cite this article

Abstract

Evidence is presented that a small protein (VPg) is covalently attached to the 5′-terminal oligonucleotide VPg–pU-U–A–A–A–A–C–A–Gp of the polio genome, to nascent strands of the polio replicative intermediate and to poly(U) of minus strands. A model of polio RNA replication is proposed implicating VPg in initiation of RNA synthesis, possibly as primer.

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Authors and Affiliations

  1. Department of Microbiology, School of Basic Health Sciences, State University of New York at Stony Brook, Stony Brook, New York, 11794

    Akio Nomoto, Barbara Detjen, Rudy Pozzatti & Eckard Wimmer

Authors
  1. Akio Nomoto
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  2. Barbara Detjen
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  3. Rudy Pozzatti
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  4. Eckard Wimmer
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Nomoto, A., Detjen, B., Pozzatti, R. et al. The location of the polio genome protein in viral RNAs and its implication for RNA synthesis. Nature 268, 208–213 (1977). https://doi.org/10.1038/268208a0

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  • DOI: https://doi.org/10.1038/268208a0

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