miRNAs articles from across Nature Portfolio

Here the authors developed and experimentally validated sChemNET, a deep learning framework to predict small molecules affecting microRNA function based on chemical structure and sequence data. sChemNET predicts bioactive small molecules on the basis of sparse chemical datasets.

Binding of microRNA-21-3p to the fatty acid metabolism-related target gene affects the development of chronic heart failure.

miRNAs play a crucial role in biological processes and their dysregulation is associated with many diseases and disorders. Here, the authors develop a method to manipulate miRNAs via RNA editing of their precursors and apply this method to program stem cell differentiation for bone tissue regeneration.

Small extracellular vesicles (sEVs) derived from the blood of young mice are shown to have the potential to extend lifespan and rejuvenate physiological functions in aged mice. Mechanistically, microRNA (miRNA) cargoes within these sEVs alleviated age-related dysfunction by promoting the expression of PGC1α and enhancing mitochondrial energy metabolism.

Joana Vidigal reminds us of the first paper to report an endogenous role of the nucleolytic activity of the mammalian RNAi protein argonaute-2.

RNA modifications have emerged as key gene regulators. A new study shows that increased levels of reactive oxygen species in cancer induce widespread, sequence-specific modifications of guanines in the seed regions of microRNAs, altering the targets of those miRNAs and influencing tumorigenesis.

Wagner et al. report an organism-wide map of non-coding RNA expression in ageing and rejuvenated mice, identifying a set of broadly deregulated microRNAs that may act as systemic regulators of ageing.

Marina Chekulaeva describes the experiments that showed that microRNAs cause degradation of their target mRNAs.

A report in Molecular Cell identifies six new triggers of target-directed miRNA degradation, which are essential for normal Drosophila melanogaster embryogenesis.