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Biomaterial design for proactive modulation of the complement system

Nature Reviews Bioengineering (2025)Cite this article

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Redesigning biomaterials to proactively modulate the complement system can reduce unintended immune responses and enhance their therapeutic efficacy.

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Fig. 1: Strategies for biomaterial interaction with the complement system.

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Acknowledgements

This paper was supported by the National Natural Science Foundation of China (W2411085), Noncommunicable Chronic Diseases-National Science and Technology Major Project (2023ZD0500700) and the Shanghai Municipal Health Commission (2022XD055).

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  1. These authors contributed equally: Adilijiang Abudousu, Yunkai Tang.

Authors and Affiliations

  1. Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

    Adilijiang Abudousu, Yunkai Tang, Zhen Wang, Feng Lin & Wenguo Cui

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  1. Adilijiang Abudousu
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  2. Yunkai Tang
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Correspondence to Wenguo Cui.

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Abudousu, A., Tang, Y., Wang, Z. et al. Biomaterial design for proactive modulation of the complement system. Nat Rev Bioeng (2025). https://doi.org/10.1038/s44222-025-00281-x

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