Universal Pictures' last theatrically released traditionally animated movie, for now, as well as Universal Pictures' first fully animated movie to have a theatrical release since Balto (1995).
This was originally going to be made into a live-action/animated movie in the early 1990s.
The creators of the original Curious George, the Reys, fled Paris, France, just before Hitler's army invaded during WWII on home made bicycles and managed to take a few in-progress manuscripts with them.
The ship that takes Ted and George to the U.S. is named "H.A. Rey", after the author of the Curious George books, Hans Augusto Rey.
David Cross' first time voice acting in a theatrically released film. Later he went onto voice Giddy in Cuộc Chiến Ở Terra (2007), Crane in the Kung Fu Panda films, and Minion in Kẻ Xấu Đẹp Trai (2010).