- He has an identical twin brother named Sami.
- His parents are Egyptian. He has also said that he has "an eighth Greek" ancestry.
- He had the Freddie Mercury teeth he wore while filming Bohemian Rhapsody: Huyền Thoại Ngôi Sao Nhạc Rock (2018) cast in gold.
- His identical twin brother Sami, who is younger by four minutes, is a teacher.
- Was in a relationship with his Bohemian Rhapsody: Huyền Thoại Ngôi Sao Nhạc Rock (2018) co-star Lucy Boynton from 2018 until 2023.
- His late father was a tour guide in Cairo and later sold insurance. His mother is an accountant.
- Went to high school with Kirsten Dunst, where he was a year ahead. They had a musical theater class together.
- Has also an older sister, who is a medical doctor.
- Went to high school with and once dated his Siêu Hacker (2015) co-star Christian Slater's stepsister Emily.
- Graduated from Notre Dame High School in Sherman Oaks, Los Angeles, in June 1999. Two of his classmates were Rachel Bilson and Taylor Fry. Kirsten Dunst graduated from the same school a year later, and Katharine McPhee graduated three years after Rami.
- Received his Bachelor of Fine Arts degree in 2003 from the University of Evansville in Evansville, Indiana.
- Received his BFA from the University of Evansville.
- Raised in the Coptic Orthodox faith.
- Almost reprised his role as Freddie Mercury in a cameo appearance in Người Hoả Tiễn (2019), before the producers ultimately decided against it.
- Won the 2019 Academy Award in the Best Actor in a leading Role category for his role as Freddie Mercury in Bohemian Rhapsody: Huyền Thoại Ngôi Sao Nhạc Rock (2018).
- He is the fifth Oscar winning actor to play a villain in a James Bond film after Christopher Walken, Benicio Del Toro, Javier Bardem, and Christoph Waltz.
- Won the 2019 Golden Globe Award in the Best Performance by an Actor in a Motion Picture - Drama category for his role as Freddie Mercury in Bohemian Rhapsody: Huyền Thoại Ngôi Sao Nhạc Rock (2018).
- Second actor with ancestry from an Arab country to win the Academy Award for Best Actor. F. Murray Abraham, who won for Sự Đố Kỵ Của Thiên Tài (1984), is the first.
- He is the second male born after 1980 to have won an acting Oscar. Eddie Redmayne, who won Best Actor for Thuyết Yêu Thương (2014), is the first.
- Attended the worldwide Women's March protest, while he was in Paris, France.
- The first American actor to play a main James Bond villain since Robert Davi in 1989.
- Raised in Los Angeles.
- (February 24, 2019) Rami's Best Actor Oscar for Bohemian Rhapsody: Huyền Thoại Ngôi Sao Nhạc Rock (2018) was presented to him by Gary Oldman and Allison Janney (Dolby Theatre, Los Angeles).
- Is good friends with Bassam Habib.
- Born at 8:41 AM (PDT).
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