- He has played five characters in the last three Star Trek (1966) spin-offs.
- Before playing the President of the United States on 24h Chống Khủng Bố (2001), he played a presidential candidate in a commercial for cheese.
- According to the producers of 24h Chống Khủng Bố (2001), his resemblance to president Richard Nixon was not deliberate; it was merely a coincidence.
- Lives in Los Angeles with his wife, an artist, and their two children Wilke (b. 1983) and Julia (b. 1986).
- Starred in two unrelated movies dealing with Abraham Lincoln: "The Day Lincoln Was Shot" (as Mr. Crook) and "Lincoln" (as John Campbell).
- Was nominated for Broadway's 1994 Tony Award as Best Actor (Featured Role - Play) for "The Kentucky Cycle".
- Although he played Fionnula Flanagan's son in Star Trek: Deep Space Nine (1993), he is only six years her junior in real life.
- Appeared in both Airplane movies, but as different characters.
- He was awarded the 1992 Drama Logue Award for Outstanding Performance for "The Kentucky Circle" at the Mark Taper Forum Theatre in Los Angeles, California.
- When he was in sixth grade, his family moved to Burlington, Wisconsin, where his father was mayor.
- He was nominated for a 1994 Antoinette Perry (Tony) Award for Best Featured Actor for "The Kentucky Cycle" on Broadway in New York City.
- Survived by his wife, one daughter Julie, one son, Wike, one grandson, Wylder Gregory, sister Pamela, niece and nephew Deidre and Cole great niece and nephew Claire and Cole.
- Lois Foraker, Marnie Mosiman and he were awarded the 1986 Drama Logue Award for Outstanding Direction and Concept for "Rogues Gallery," in a Sundays at the Itchey Foot production at the Mark Taper Forum Theatre in Los Angeles, California.
- In 2010, he appeared as the Earl of Kent in the Antaeus Company's production of King Lear. He won the L.A. Drama Critics Circle Award for this performance.
- Itzin originally intended to become a theater actor, receiving training at the American Conservatory Theater in San Francisco.
- His father was of German descent and his mother had Irish and English ancestry.
- He has played in several radio plays with The L.A. Theatre Works, and most recently played the Archbishop in the Hollywood Theater of the Ear's 2010 audio production of Saint Joan.
- He hosted ACME: This Week! at the ACME Comedy Theatre on February 23, 2008, appearing in several sketches as well as a short film, "Law and Order: Really Special Victims Unit".
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