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Ben Matlock is a very expensive criminal defense attorney, who charges one hundred thousand dollars to take a case. Fortunately, he's worth every penny, as he and his associates defend his clients by finding the real killer.

Dr. Mark Sloan has a knack for getting into trouble, negotiating the twists and turns of mysteries and solving crimes with the help of his son, Steve, a homicide detective.

Veteran district attorney "Fatman" McCabe solves cases with the help of his easygoing private investigator partner Jake Styles.

An amiable, inquisitive Chicago priest moonlights as a detective and is assisted by a rather worldly, lock-picking nun.

Dr Sheila Carlin is good friends with Della who calls Perry in when she is being pestered by someone. On the theory that it could be somebody that she works with at a radio stations she arranges Perry to be interviewed by Winslow Keene who is also the station's owner. Winslow enrages the rest of the talk show hosts on the station by informing them of changes that he is making to their time slots. That night, Winslow is shot by a hit man hired by someone at the station and Sheila is set up for the murder. She calls in Perry and as usual Perry, Della and Ken swing into action to find out who really did it...

On the set of a popular daytime soap opera 'Mile High', actress Kris Buckner is being forced off by co-star Mark Stratton. When she says that she'll 'kill him before she leaves the show', she makes herself the prime suspect when Stratton is murdered by someone poisoning him. As an old friend, Perry Mason comes to the help of Kris and agrees to defend her. Meanwhile Ken goes in search of information with the help of fan of the show.

Dr. Mark Sloan investigates when a good friend (Bill Bixby) is accused of murdering his boss.

Anthony Caruso, an old friend of Perry Mason, comes to Denver on the request of Dee Morrison. She's married to famed photographer David Morrison, who wants to shoot a photo featuring his former models. The tricky thing is that all of his former models are also his former wives. But Dee knows Anthony can convince them to do it which he does. And David shoots them. Later Dee catches David it what appears to be in an inappropriate situation with his assistant. They have an argument and she leaves. Later David is found dead and she's arrested and Anthony defends her. And he suspects it could have been one of the wives.

An old flame of Mason's is up for a government position. A man tries to blackmail her, telling her husband her secret will prevent her appointment. When the husband approaches him, he finds he is dead and gets himself charged with murder.

A dead body washes up on the ocean. Steve's investigation leads to a farm with migrant workers. The migrant workers are dying from an unknown ailment and Mark struggles to find the cause.

An editor of a fashion magazine writes a column that destroys careers. She is also a brutal employer. An editor of a rival magazine visits, asking she not be the next victim. The first is found dead and the rival is charged with murder.

Thatcher Horton is owner of a Denver sports arena and a couple of sports teams. Bobby Spencer a friend of Ken was one of his hockey players. It seems that Horton verbally promised him that he would take care of him if he gets injured, which happened. Now it seems that Horton is reneging and he has asked Ken to represent him in his suit against Horton. Bobby threatened Horton and not long after that Horton was killed and the murder weapon was found in Bobby's possession. So Perry comes to help defend Bobby. It seems that Horton was not liked by other people including his wife and son, and it also seems that the killer was a professional assassin, so did one of them hire him?

Ken Malansky is a student taught by Perry. Ken hears his girlfriend was assaulted by another student so he confronts him but finds him dead, the weapon his own knife. Perry is slow to take the case as the victim is a close friend's son.

Dr. Mark Sloan and his son Steve go to the desert to learn the fate of Mark's daughter and her new husband.

A tennis player is accused to having killed his wife, a rich heiress. The facts are against him as he was seen in the arms of his former girlfriend in the night before the murder. This is a case for Perry Mason.

Perry Mason must defend the son of an old friend who is accused of killing an ex-officer of the Nazi-SS.

Perry is at TV station "KGGY" to be interviewed but thanks to the interference of main anchor-person Brett Huston the interview is pulled. Mostly everybody hates Brett as Brett knows all the station workers secrets. He has also written a memo insulting all of the main station players - Vic St. John - the station manager, Twyla Cooper - the producer, Chuck Gilmore - the sports reporter, Gary Slate - the weatherman, Cassie Woodfield - the reporter and Gillian Pope. Brett is shot dead with Gillian's gun and therefore she is arrested for the crime. Gillian calls in Perry, Della and Ken to investigate. As Della and Perry set out to solve the mystery, Ken gets close to Cassie but she is a suspect and when it appears that somebody is trying to kill her, the mystery deepens...

When gubernatorial candidate Harlan Richards is murdered, the suspicions fall on the incumbent Governor Ryan Allison but when he, too, is murdered the plot thickens.

In this episode Perry Mason defends a young theatre director who is accused to have killed a famous director of a Broadway musical.

The chief suspects in the murder of an author are the numerous colleagues whom he continuously plagiarized.

Perry Mason defends the husband of a famous pop singer who was found shot to death after having had an argument with her husband who was also her manager.

Frank Dowling has to solve the mystery of a young man who is obsessed with finding his natural parents.

Alana, a maverick owner of a cosmetics company, reveals she's 60. She's kept her age a secret and credits the cream for her youthful appearance. She's murdered and the formula is missing. Her husband is arrested and Perry defends him.

Bill McKenzie's niece works as a production assistant for controversial television personality Josie Joplin, who publicly accuses her of having an affair with her husband. One night McKenzie's niece receives a message which she believes is from Josie to go to her hotel room, when she gets there someone knocks her out and when she wakes up, Josie is dead and she's the number one suspect, so McKenzie defends her.

Dr Mark Sloan cannot believe that his former student Dr Drummond, an ambitious cosmetic surgeon, has committed suicide. Assisted by his team of hobby detectives, pathologist Amanda Bentley and junior doctor Jack Parker, Sloan tries to investigate the case. He finds out that Drummond and his senior partner, Dr Stern, had used plastic surgery to create a double of rich banker and benefactor Gantry, who is expected to make a major donation to the community hospital. Does Gantry also plan to have his double assassinated in order to vanish with the money himself?