- She was born in Addis Ababa, Ethiopia, to an Ethiopian father and Irish mother. She was raised in Limerick, Ireland, from the age of four.
- Has been chosen as the Irish Shooting Star for the Berlin Film Festival.
- Her last name Negga means dawn in Amharic and it's very common.
- She was nominated for a 2004 Laurence Olivier Theatre Award for Most Promising Newcomer of 2003 in a Society of London Theatre Affiliate Theatre for her performance in Duck at the Jerwood Theatre Upstairs at the Jerwood Court.
- Has attracted special praise for her stage performances in "Hamlet" in Dublin, London and New York, not only for portraying Ophelia, but also the male title role of Hamlet.
- Her favourite films are All About Eve (1950), Bringing Up Baby (1938), Big Business (1988), Outrageous Fortune (1987), Truyền Thuyết (1985) and Labyrinth (1986).
- Is one of 20 actresses to have received a Best Actress Oscar nomination for a performance where they acted out a labor and/or birth; hers being for Yêu (2016). The others in chronological order are Luise Rainer for The Good Earth (1937), Jane Wyman for Johnny Belinda (1948), Eleanor Parker for Caged (1950), Elizabeth Taylor for Raintree County (1957), Leslie Caron for The L-Shaped Room (1962), Shirley MacLaine for Irma la Douce (1963), Vanessa Redgrave for Isadora (1968), Geneviève Bujold for Anne of the Thousand Days (1969), Marsha Mason for Cinderella Liberty (1973), Ann-Margret for Tommy (1975), Ellen Burstyn for Same Time, Next Year (1978), Jessica Lange for Sweet Dreams (1985), Meryl Streep for Evil Angels (1988), Samantha Morton for In America (2002), Elliot Page for Dính Bầu (2007), Gabourey Sidibe for Cô Bé Precious (2009), Yalitza Aparicio for Khu Phố Roma (2018), Vanessa Kirby for Những Mảnh Vỡ Của Người Phụ Nữ (2020) and Penélope Cruz for Madres paralelas (2021).
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