- Her real-life daughter, Salome Violetta Haertel, played her daughter "Ella Greene" in ER (1994)'s Season 8 episode On the Beach (2002).
- She was born to an English father and a German mother, and is fluent in German.
- Voted Best Supporting Actress for her work on 2010 by readers of Doctor Who Magazine.
- A former member of the Royal Shakespeare Company and has performed extensively in the theater.
- Reported as leaving ER (1994) because producers believe her character, icy surgeon Elizabeth Corday, has "run its course" and did not renew her contract. Interviewed in UK's Radio Times Magazine she said she had become "deeply unhappy" on the show and was aware she was being used less. (June 2004)
- Attended RADA (Royal Academy of Dramatic Arts) where she met her husband, actor Ralph Fiennes. The couple separated on 13 October 1995.
- Mother, with ex-husband Florian Haertel, of daughter Salome Violetta Haertel (b. March 28, 2001).
- (July 18, 2015) Married her longtime boyfriend Jonathan Stamp in Rome, Italy, following a year-long engagement.
- On Law & Order SVU she played Miranda Pond. Later, on Dr. Who she played Melody Pond (a.k.a. River Song).
- Her ex-husband, Florian Haertel, is a German freelance journalist.
- Has two younger sisters. One is named Nichola.
- Parents are Margarethe and Anthony.
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