- Was immortalized in the song "Rosanna" written and performed by TOTO (on their album, Toto IV). "Rosanna" was a Top 10 hit that went on to win Grammys for 1982: Record of the Year, Best Pop Vocal Performance, and Best Instrumental Arrangement With Vocal. Rosanna was the girlfriend of a member of the band, Steve Porcaro.
- Lived in England with singer-songwriter Peter Gabriel from 1988 to 1992.
- Was among over 80 women who accused Harvey Weinstein of sexual abuse in October 2017.
- Was considered for the role of Sarah Connor in Kẻ Hủy Diệt (1984), considered for the role of rape victim "Sarah Tobias" in Jonathan Kaplan's The Accused (1988), eventually played by Jodie Foster, who won an Academy Award for her performance. She also Auditioned for the role of Emmeline Lestrange in Eo Biển Xanh (1980) which went to Brooke Shields.
- The family surname was spelled as Arcouet many generations back. Her father had French-Canadian, English, Swiss-German, German, Scottish, Irish, and Welsh ancestry. Rosanna's maternal grandfather, Yusseff "Joseph" Nowack, was a Jewish emigrant from Bila Zerkwa, Kiev, then in the Russian Empire, while Rosanna's maternal grandmother, Claire Hibel, was born in New York, to Russian Jewish parents.
- Daughter of Lewis Arquette and Brenda Denaut. Granddaughter of Cliff Arquette and Julie Harrison. Older sister of Richmond Arquette, Alexis Arquette, David Arquette and Patricia Arquette. Aunt of Enzo Rossi and Harlow Jane (Patricia's children), Coco Arquette and Charlie West & Augustus Alexis Arquette (David's children).
- Only one of her five siblings to never appear in a major horror film series. Each of her siblings has appeared in at least one including Nightmare on Elm Street, Children of the Corn, Child's Play and Scream.
- Formerly sister-in-law of Nicolas Cage, who was married to her sister, Patricia Arquette. Former sister-in-law of Thomas Jane and Courteney Cox.
- Sister-in-law of Christina McLarty Arquette, David's second wife.
- Her mother died of breast cancer
- Shared an on-screen husband with her real-life sister-in-law, Courteney Cox. Matthew Perry was her husband in The Whole Nine Yards (2000) and also played Courteney Cox's husband, "Chandler" on Những Người Bạn (1994). Courteney Cox Arquette was married to David Arquette, her brother.
- Was considered for the role of rape survivor "Sarah Tobias" in Jonathan Kaplan's The Accused (1988), eventually played by Jodie Foster, who won an Academy Award for her performance.
- Has a daughter, Zoë Bleu Sidel (b. October 23, 1994), with her ex-third husband John Sidel.
- Peter Gabriel's song "In Your Eyes" is inspired by her.
- Played Angelina Jolie's mother in Hell's Kitchen (1998) and Jon Voight's girlfriend on Ray Donovan (2013).
- She has appeared in two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Desperately Seeking Susan (1985) and Chuyện Tào Lao (1994).
- Announced engagement to Immortal Entertainment president David Codikow. (September 5, 2001)
- Longtime friend of Kimberly Beck.
- Born on Monday at 4:45 PM-EDT.
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