First off, stop reading about this show, just watch it, go in knowing nothing. I had never seen anything besides a couple random 15 second ads for the show that didn't make sense at the time, but now it all clicks. I have never laughed so hard at a premier of a show in my life and I was watching it by myself and sober (though I do think that might be the ideal way to watch this show as it somehow adds to it all).
If you're a male in your 20s you will have no problem relating to this show, though everyone will find something to relate to just the further away you are from that benchmark the less you might relate. I'll admit I fall into that bucket and the show just hits everything on the head.
I'll be very interested to see how this show progresses because it is so extremely novel one does fear it might run out things to cover. I've yet to see signs of that, but I'm only 4 episodes in. So we'll see, I remain hopeful, go watch it!
