Eric Bauza was originally cast as Dudley Puppy. But creator Butch Hartman felt the voice didn't feel right, and thus the role was recast.
The third show ever created by Butch Hartman after The Fairly OddParents and Danny Phantom.
Butch Hartman has depicted T.U.F.F. Puppy as "Get Smart with a dog", likely owing to the influence of the 1960s spy spoof show Get Smart.