- DVD and Blu-ray include 29 minutes long original ending and three alternate endings.
- Unreleased deleted scene; After 'Rusty Nail' drives away in his truck after almost crushing Lewis and Fuller in their car, the two look at each other, and begin to laugh timidly. Then Fuller, slowly steps out of the car and screams at the top of his lungs.
- The DVD and Blu-Ray include four alternate endings, all of which were taken from few workprints of the film, which is why they're not shown in greatest quality. Three of the alternate endings are just alternate versions of the re-shot ending used in final film. However, in all three, the two brothers physically fight Rusty Nail behind the hotel rather than Rusty Nail getting in his truck and plowing it into the hotel. In all three endings the following occurs:
- Lewis gets into the truck and plows it into Rusty Nail. As he is walking away from the truck, Rusty Nail grabs him from underneath and tries to pull him back. Fuller runs to the front to stop the police from entering Room 18, but they hold him down and bust in anyways.
- In the first ending Lewis is able to break the board that is supporting the truck and it comes crashing down on top of Rusty Nail.
- In the second ending, Venna is able to get out of the chair. She shoots Rusty Nail with the shotgun as he is trying to pull Lewis under the truck.
- In the third ending, which was never actually finished, and is edited with footage from other endings and storyboards, Lewis ramming Rusty Nail with the truck knocks Rusty into the hotel room. Lewis and Rusty fight behind Venna as the police bust into the room. As they do, Lewis pushes Venna out of the way of the shotgun blast, and it ends up killing Rusty.
- The fourth ending, which is actually an original ending filmed during initial filming in 1999, has completely different third act; It begins with the brothers naked at the rest stop. As Venna is talking to Rusty Nail, she mentions how about 70% of psychotic killers end up killing themselves. She sees Rusty Nail pull up behind her and honks. The brothers run out, Fuller getting dressed and getting into the car, Lewis running naked across the parking lot to cut off Rusty Nail. Fuller and Venna get in the car chase after Rusty Nail. As they run along side the semi truck up an off ramp, they are forced off the road by an oncoming car. Fuller swerves to miss the car and Lewis' car flips down a hill. After Fuller gets out of the car, the man in the other car punches him and begins fighting Lewis as he comes running up. Venna hears Charlotte screaming on the CB as the police show up. The next scene is in the police station with the brothers behind bars. Venna is talking with the police chief and tells him that she is not leaving until they find Charlotte. She also finds out that Ellinghouse, the man who had his jaw ripped off, has died from his wounds. Rusty Nail calls the brothers on the station phone. The police trace the call as Rusty Nail says that Venna made a lot of sense when she was talking about psychotic killers killing themselves. We hear a gun blast over the phone as the police trace the call. When they get to the phone, they find a dead body in a pay phone with a shotgun blast to the face. They also find Charlotte in the back of a trailer bed. Venna goes with Charlotte in an ambulance, while one of the officers takes the brothers. On the way back to the station, they realize that the dead body in the phone booth was the Ice Truck driver. Lewis steals the officer's gun and his car. Fuller has the option of staying with the officer and saving himself a felony charge but chooses to go with Lewis. They find the ambulance flipped upside down. Charlotte is there, Venna is gone, and the driver is rambling about Rusty Nail taking Venna. The words "DRINK UP!" are spray painted on the side of the ambulance and the pink champagne bottle is inside. The brothers continue down the road in the stolen police car. They come upon Rusty Nail and pull him over next to a corn field with the police siren. Fuller dresses as a cop to distract Rusty Nail as Lewis gets in back to find Venna. Rusty Nail eventually realizes this is what is going on and backs the truck into the police car forcing it into a ditch. Rusty Nail drives off with Lewis and Venna still in the back, but they eventually jump out. Fuller runs up to meet them as Rusty Nail gets out of his truck. He unlatches the trailer bed and comes after them with the semi. They run into the corn field in pretty much the same scene that is in the final film. This is why if you look closely in the movie's version of the scene you can see Fuller wearing a cop hat and jacket, and lot of the behind the scenes material and promotional stills also show parts of this original ending. The only difference is they all stay together and they eventually come upon a tractor with a tank of Ammonia Nitrate. Lewis gets the idea of blowing up Rusty Nail and tells Fuller and Venna to run. They do, and Lewis gets Rusty Nail's attention. The semi truck comes after him and hits the gas tank, but it does not blow up. Instead, the truck is pushing the tank after Lewis. Fuller and Venna get out of the corn field and turn to see Lewis close behind. Lewis screams for Fuller to shoot the gas tank with the officer's gun. Fuller finally hits the tank and the truck explodes. The three watch the truck burn as the police arrive. At the hospital, Lewis and Venna finally kiss. Fuller thinks he could make a pretty good cop. Paramedics show up with Rusty Nail and try to revive him. As the three watch on, Rusty Nail finally dies. Fuller says he can't believe it, but he actually wants to go home.
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