When an unnatural disaster occurs on Earth due to the beginning of a celestial event known as the Grand Cross, the five Tatsumi siblings unexpectedly reunite as their father returns and summons them to stop a potential calamity as GoGoFive.
Matsuri's consideration for the elderly comes under fire from her siblings as well as from Drop's Psyma Beast whose weather control hurts an elderly man's beloved flowers.
Shou quits GoGoFive to push forwards his dreams as a pilot, even as his department is targeted by a Psyma Beast for an experimental killer mold being transported.
Nagare and Matsuri are assigned to protect a scientist with a valuable payload, while Denus takes over Cobolda's mission in obtaining it for the Psyma.
The commissioner of the fire department forces Mondo to shut down GoGoFive due to risking his own children in using his rescue technology above his orders.
With Victory Robo crushed by two strengthened Psyma Beasts, GoGoFive must protect the people trapped by the volcano while Mondo makes a move to help his children with an untested new weapon.
GoGoFive face their greatest threat in protecting the city against three powerful beings from Hell summoned by Zylpheeza to force them into a hopeless corner.
After experiencing their first utter defeat from the Psyma Hell Siblings, GoGoFive must figure out a means to defeat them while reaffirming their mission as rescue heroes.
The Tatsumi siblings discover blueprints that make them believe they are gaining a 6th member as the remaining Hell Siblings are sent out by a worrying Zylpheeza.
On the day of the Grand Cross, GoGoFive work to keep the city from being destroyed as Mondo tries to stop Grandiene's descent to Earth from being complete.
While their father is in critical condition from his encounter with the Psyma, Matsuri rescues a boy with a peculiar power and no memory of who he really is.
As the asteroid Grandeo approaches Earth, GoGoFive must undertake a risky mission with a new mecha in order to prevent it from collision and granting Grandiene her complete form.
Salamandes captures the younger Tatsumi siblings within a frigid wasteland inside a Psyma Beast, forcing Matoi to rescue them to prove his sibling bond is greater.
A fellow paramedic gains Matsuri's support to propose to a female co-worker, making the elder Tatsumi brothers believe that their little sister is getting married.
With the knowledge of the Infinity Chain Card, Nagare tries to figure a way to defeat it once and for all, even as Matoi keeps claiming that he's being too technical in his ways.
Matoi decides to settle things with an elder rival in from New York while the team tries to investigate strange earthquakes caused by an underwater Psyma Beast.
On Christmas Eve, the anniversary of their mother's birthday and disappearance, GoGoFive becomes trapped by Salamandes in a hell where ghost Psyma Beasts attack with no end.
When a robotic partner of Shou's becomes infected with Minus Energy by Pierre, he becomes torn when Nagare tells him that it can't be saved and must be destroyed.
Cobolda and Denus use Matoi's fighting spirit to revive their elder brother Zylpheeza, forcing his younger siblings to stop him from reaching full power.
Merging with the Minus Energy of the universe, Grandiene resurrects Salamandes and Zylpheeza to destroy Earth, forcing GoGoFive to both save their town and to defeat her two ultimate heralds.
As Grandiene infuses all of her power within her two avatars of destruction, GoGoFive must both save Earth and their home as the final fate of the Tatsumi family is determined.
