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RAD51

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RAD51 je eukariotski gen. Protein kodiran ovim genom je član RAD51 proteinske familije koja pomaže u popravci dvolančanih prekida DNK. Članovi RAD51 familije su homologni sa bakterijkim RecA i kvaščanim Rad51. Ovaj protein je visoko konzerviran kod većine eukariota, od kvasca do ljudi.

RAD51 homolog (S. cerevisiae)

Rad51 filament baziran na 1SZP.[1]
Dostupne strukture
1B22, 1N0W
Identifikatori
SimboliRAD51; BRCC5; HRAD51; HsRad51; HsT16930; RAD51A; RECA
Vanjski IDOMIM: 179617 MGI: 97890 HomoloGene: 2155 GeneCards: RAD51 Gene
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez588819361
EnsemblENSG00000051180ENSMUSG00000027323
UniProtQ06609Q08297
RefSeq (mRNA)NM_001164269.1NM_011234.4
RefSeq (protein)NP_001157741.1NP_035364.1
Lokacija (UCSC)Chr 15:
40.99 - 41.02 Mb		Chr 2:
118.94 - 118.97 Mb
PubMed pretraga[1][2]

Varijante

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Dve alternativno splajsovane transkriptne varijante ovog gena, koje kodiraju zasebne proteina, su poznate. Transkriptne varijante koje koriste alternativne polyA signale postoje.

Interakcije

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RAD51 možed da formira interakcije sa BRE,[2] RAD54B,[3] Serinska proteinska kinaza ATM,[4] BRCC3,[2] BARD1,[2] BRCA2,[2][5][6][7][8][9][10][11][12][13][14][15][16] UBE2I,[17][18] Abl gen,[4] BRCA1,[2][15][19][20] ATRX,[3][21] RAD52,[4] DMC1,[22] P53[2][23][24] i Protein Blumovog sindroma.[25]

Reference

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  1. ↑ Conway AB, Lynch TW, Zhang Y, Fortin GS, Fung CW, Symington LS, Rice PA. (2004). „Crystal structure of a Rad51 filament”. Nat Struct Mol Biol 11 (8): 791–6. PMID 15235592. 
  2. ↑ 2,0 2,1 2,2 2,3 2,4 2,5 Dong, Yuanshu; Hakimi Mohamed-Ali, Chen Xiaowei, Kumaraswamy Easwari, Cooch Neil S, Godwin Andrew K, Shiekhattar Ramin (November 2003). „Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair”. Mol. Cell (United States) 12 (5): 1087–99. DOI:10.1016/S1097-2765(03)00424-6. ISSN 1097-2765. PMID 14636569. 
  3. ↑ 3,0 3,1 Tanaka, K; Hiramoto T, Fukuda T, Miyagawa K (August 2000). „A novel human rad54 homologue, Rad54B, associates with Rad51”. J. Biol. Chem. (UNITED STATES) 275 (34): 26316–21. DOI:10.1074/jbc.M910306199. ISSN 0021-9258. PMID 10851248. 
  4. ↑ 4,0 4,1 4,2 Chen, G; Yuan S S, Liu W, Xu Y, Trujillo K, Song B, Cong F, Goff S P, Wu Y, Arlinghaus R, Baltimore D, Gasser P J, Park M S, Sung P, Lee E Y (April 1999). „Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl”. J. Biol. Chem. (UNITED STATES) 274 (18): 12748–52. DOI:10.1074/jbc.274.18.12748. ISSN 0021-9258. PMID 10212258. 
  5. ↑ Sharan, S K; Morimatsu M, Albrecht U, Lim D S, Regel E, Dinh C, Sands A, Eichele G, Hasty P, Bradley A (April 1997). „Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2”. Nature (ENGLAND) 386 (6627): 804–10. DOI:10.1038/386804a0. ISSN 0028-0836. PMID 9126738. 
  6. ↑ Lin, Horng-Ru; Ting Nicholas S Y, Qin Jun, Lee Wen-Hwa (September 2003). „M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex”. J. Biol. Chem. (United States) 278 (38): 35979–87. DOI:10.1074/jbc.M210659200. ISSN 0021-9258. PMID 12815053. 
  7. ↑ Yu, David S; Sonoda Eiichiro, Takeda Shunichi, Huang Christopher L H, Pellegrini Luca, Blundell Tom L, Venkitaraman Ashok R (October 2003). „Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2”. Mol. Cell (United States) 12 (4): 1029–41. DOI:10.1016/S1097-2765(03)00394-0. ISSN 1097-2765. PMID 14580352. 
  8. ↑ Chen, P L; Chen C F, Chen Y, Xiao J, Sharp Z D, Lee W H (April 1998). „The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (9): 5287–92. DOI:10.1073/pnas.95.9.5287. ISSN 0027-8424. PMC 20253. PMID 9560268. 
  9. ↑ Sarkisian, C J; Master S R, Huber L J, Ha S I, Chodosh L A (October 2001). „Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals”. J. Biol. Chem. (United States) 276 (40): 37640–8. DOI:10.1074/jbc.M106281200. ISSN 0021-9258. PMID 11477095. 
  10. ↑ Wong, A K; Pero R, Ormonde P A, Tavtigian S V, Bartel P L (December 1997). „RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2”. J. Biol. Chem. (UNITED STATES) 272 (51): 31941–4. DOI:10.1074/jbc.272.51.31941. ISSN 0021-9258. PMID 9405383. 
  11. ↑ Katagiri, T; Saito H, Shinohara A, Ogawa H, Kamada N, Nakamura Y, Miki Y (March 1998). „Multiple possible sites of BRCA2 interacting with DNA repair protein RAD51”. Genes Chromosomes Cancer (UNITED STATES) 21 (3): 217–22. DOI:10.1002/(SICI)1098-2264(199803)21:3<217::AID-GCC5>3.0.CO;2-2. ISSN 1045-2257. PMID 9523196. 
  12. ↑ Pellegrini, Luca; Yu David S, Lo Thomas, Anand Shubha, Lee MiYoung, Blundell Tom L, Venkitaraman Ashok R (November 2002). „Insights into DNA recombination from the structure of a RAD51-BRCA2 complex”. Nature (England) 420 (6913): 287–93. DOI:10.1038/nature01230. ISSN 0028-0836. PMID 12442171. 
  13. ↑ Tarsounas, Madalena; Davies Adelina A, West Stephen C (January 2004). „RAD51 localization and activation following DNA damage”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (England) 359 (1441): 87–93. DOI:10.1098/rstb.2003.1368. ISSN 0962-8436. PMC 1693300. PMID 15065660. 
  14. ↑ Liu, J; Yuan Y, Huan J, Shen Z (January 2001). „Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2”. Oncogene (England) 20 (3): 336–45. DOI:10.1038/sj.onc.1204098. ISSN 0950-9232. PMID 11313963. 
  15. ↑ 15,0 15,1 Chen, J; Silver D P, Walpita D, Cantor S B, Gazdar A F, Tomlinson G, Couch F J, Weber B L, Ashley T, Livingston D M, Scully R (September 1998). „Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells”. Mol. Cell (UNITED STATES) 2 (3): 317–28. DOI:10.1016/S1097-2765(00)80276-2. ISSN 1097-2765. PMID 9774970. 
  16. ↑ Marmorstein, L Y; Ouchi T, Aaronson S A (November 1998). „The BRCA2 gene product functionally interacts with p53 and RAD51”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (23): 13869–74. DOI:10.1073/pnas.95.23.13869. ISSN 0027-8424. PMC 24938. PMID 9811893. 
  17. ↑ Kovalenko, O V; Plug A W, Haaf T, Gonda D K, Ashley T, Ward D C, Radding C M, Golub E I (April 1996). „Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (7): 2958–63. DOI:10.1073/pnas.93.7.2958. ISSN 0027-8424. PMC 39742. PMID 8610150. 
  18. ↑ Shen, Z; Pardington-Purtymun P E, Comeaux J C, Moyzis R K, Chen D J (October 1996). „Associations of UBE2I with RAD52, UBL1, p53, and RAD51 proteins in a yeast two-hybrid system”. Genomics (UNITED STATES) 37 (2): 183–6. DOI:10.1006/geno.1996.0540. ISSN 0888-7543. PMID 8921390. 
  19. ↑ Scully, R; Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston D M (January 1997). „Association of BRCA1 with Rad51 in mitotic and meiotic cells”. Cell (UNITED STATES) 88 (2): 265–75. DOI:10.1016/S0092-8674(00)81847-4. ISSN 0092-8674. PMID 9008167. 
  20. ↑ Wang, Q; Zhang H, Guerrette S, Chen J, Mazurek A, Wilson T, Slupianek A, Skorski T, Fishel R, Greene M I (August 2001). „Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1”. Oncogene (England) 20 (34): 4640–9. DOI:10.1038/sj.onc.1204625. ISSN 0950-9232. PMID 11498787. 
  21. ↑ Sigurdsson, Stefan; Van Komen Stephen, Petukhova Galina, Sung Patrick (November 2002). „Homologous DNA pairing by human recombination factors Rad51 and Rad54”. J. Biol. Chem. (United States) 277 (45): 42790–4. DOI:10.1074/jbc.M208004200. ISSN 0021-9258. PMID 12205100. 
  22. ↑ Masson, J Y; Davies A A, Hajibagheri N, Van Dyck E, Benson F E, Stasiak A Z, Stasiak A, West S C (November 1999). „The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51”. EMBO J. (ENGLAND) 18 (22): 6552–60. DOI:10.1093/emboj/18.22.6552. ISSN 0261-4189. PMC 1171718. PMID 10562567. 
  23. ↑ Stürzbecher, H W; Donzelmann B, Henning W, Knippschild U, Buchhop S (April 1996). „p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction”. EMBO J. (ENGLAND) 15 (8): 1992–2002. ISSN 0261-4189. PMC 450118. PMID 8617246. 
  24. ↑ Buchhop, S; Gibson M K, Wang X W, Wagner P, Stürzbecher H W, Harris C C (October 1997). „Interaction of p53 with the human Rad51 protein”. Nucleic Acids Res. (ENGLAND) 25 (19): 3868–74. DOI:10.1093/nar/25.19.3868. ISSN 0305-1048. PMC 146972. PMID 9380510. 
  25. ↑ Wu, L; Davies S L, Levitt N C, Hickson I D (June 2001). „Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51”. J. Biol. Chem. (United States) 276 (22): 19375–81. DOI:10.1074/jbc.M009471200. ISSN 0021-9258. PMID 11278509. 

Spoljašnje veze

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Izvor: https://sh.wikipedia.org/w/index.php?title=RAD51&oldid=15584143