GPR56
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G protein spregnuti receptor 56 je protein koji je kod ljudi kodiran GPR56 genom.[1][2][3]
| G protein spregnuti receptor 56 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | GPR56; BFPP; TM7LN4; TM7XN1 | ||||||||||
| Vanjski ID | OMIM: 604110 MGI: 1340051 HomoloGene: 4156 IUPHAR: GPR56 GeneCards: GPR56 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 9289 | 14766 | |||||||||
| Ensembl | ENSG00000205336 | ENSMUSG00000031785 | |||||||||
| UniProt | Q9Y653 | Q8K209 | |||||||||
| RefSeq (mRNA) | NM_001145770.1 | NM_001198894.1 | |||||||||
| RefSeq (protein) | NP_001139242.1 | NP_001185823.1 | |||||||||
| Lokacija (UCSC) | Chr 16: 57.64 - 57.7 Mb | Chr 8: 97.51 - 97.54 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Izražavanje GPR56 gena u melanocitnim ćelijama je regulisano MITF faktorom.[4]
Reference
uredi- ↑ Liu M, Parker RM, Darby K, Eyre HJ, Copeland NG, Crawford J, Gilbert DJ, Sutherland GR, Jenkins NA, Herzog H (May 1999). „GPR56, a novel secretin-like human G-protein-coupled receptor gene”. Genomics 55 (3): 296–305. DOI:10.1006/geno.1998.5644. PMID 10049584.
- ↑ Zendman AJ, Cornelissen IM, Weidle UH, Ruiter DJ, van Muijen GN (Apr 1999). „TM7XN1, a novel human EGF-TM7-like cDNA, detected with mRNA differential display using human melanoma cell lines with different metastatic potential”. FEBS Lett 446 (2-3): 292–8. DOI:10.1016/S0014-5793(99)00230-6. PMID 10100861.
- ↑ „Entrez Gene: GPR56 G protein-coupled receptor 56”.
- ↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). „Novel MITF targets identified using a two-step DNA microarray strategy”. Pigment Cell Melanoma Res. 21 (6): 665–76. DOI:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
Literatura
uredi- Xu L, Hynes RO (2007). „GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment.”. Cell Cycle 6 (2): 160–5. DOI:10.4161/cc.6.2.3760. PMID 17314516.
- Piao X, Basel-Vanagaite L, Straussberg R, et al. (2002). „An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21.”. Am. J. Hum. Genet. 70 (4): 1028–33. DOI:10.1086/339552. PMC 379097. PMID 11845408.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). „The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”. Genome Res. 13 (10): 2265–70. DOI:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Little KD, Hemler ME, Stipp CS (2005). „Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association.”. Mol. Biol. Cell 15 (5): 2375–87. DOI:10.1091/mbc.E03-12-0886. PMC 404030. PMID 15004227.
- Piao X, Hill RS, Bodell A, et al. (2004). „G protein-coupled receptor-dependent development of human frontal cortex.”. Science 303 (5666): 2033–6. DOI:10.1126/science.1092780. PMID 15044805.
- Zhang Z, Henzel WJ (2005). „Signal peptide prediction based on analysis of experimentally verified cleavage sites.”. Protein Sci. 13 (10): 2819–24. DOI:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Shashidhar S, Lorente G, Nagavarapu U, et al. (2005). „GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion.”. Oncogene 24 (10): 1673–82. DOI:10.1038/sj.onc.1208395. PMID 15674329.
- Sud N, Sharma R, Ray R, et al. (2006). „Differential expression of G-protein coupled receptor 56 in human esophageal squamous cell carcinoma.”. Cancer Lett. 233 (2): 265–70. DOI:10.1016/j.canlet.2005.03.018. PMID 15916848.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”. DNA Res. 12 (2): 117–26. DOI:10.1093/dnares/12.2.117. PMID 16303743.
- Xu L, Begum S, Hearn JD, Hynes RO (2006). „GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis.”. Proc. Natl. Acad. Sci. U.S.A. 103 (24): 9023–8. DOI:10.1073/pnas.0602681103. PMC 1474142. PMID 16757564.