Dipiridamol (Persantin, Antistenokardin) je lek koji inhibira formiranje tromba[6] pri hroničnoj primeni i uzrokuje vazodilataciju kad se koristi u visokim dozama tokom kratkog vremenskog intervala.
Dipiridamol
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(IUPAC) ime
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2,2',2'',2'''-(4,8-di(piperidin-1-il)pirimido[5,4-d]pirimidin-2,6-diil)bis(azanetriil)tetraetanol
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Klinički podaci
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Robne marke
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Persantin
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AHFS/Drugs.com
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Monografija
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MedlinePlus
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a682830
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Identifikatori
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CAS broj
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58-32-2
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ATC kod
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B01AC07
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PubChem[1][2]
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3108
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DrugBank
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DB00975
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ChemSpider[3]
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2997
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UNII
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64ALC7F90C Y
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KEGG[4]
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D00302 Y
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ChEBI
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CHEBI:4653 Y
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ChEMBL[5]
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CHEMBL932 Y
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Hemijski podaci
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Formula
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C24H40N8O4
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Mol. masa
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504,626 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 Y Key: IZEKFCXSFNUWAM-UHFFFAOYSA-N Y |
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Farmakokinetički podaci
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Vezivanje za proteine plazme
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99%
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Metabolizam
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Hepatic
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Poluvreme eliminacije
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Alfa (40 min), Beta (10 sati)
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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POM (UK) ℞-only (SAD)
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Način primene
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PO, IV
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Mehanizam i dejstvo
uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ „Dipyridamole at Dorland's Medical Dictionary”.