Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cell biology

Collagen secretion explained

Cells package proteins into vesicles for secretion to the extracellular milieu. A study has now identified an enzyme that modifies the packaging machinery to encapsulate unusually large proteins, such as collagen. See Article p.495

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Big vesicles for collagen secretion.

References

  1. Zanetti, G., Pahuja, K. B., Studer, S., Shim, S. & Schekman, R. Nat. Cell. Biol. 14, 20–28 (2012).

    Article  CAS  Google Scholar 

  2. Jin, L. et al. Nature 482, 495–500 (2012).

    Article  ADS  CAS  Google Scholar 

  3. Stagg, S. M. et al. Cell 134, 474–484 (2008).

    Article  CAS  Google Scholar 

  4. Fath, S., Mancias, J. D., Bi, X. & Goldberg, J. Cell 129, 1325–1336 (2007).

    Article  CAS  Google Scholar 

  5. Komander, D. Biochem. Soc. Trans. 37, 937–953 (2009).

    Article  CAS  Google Scholar 

  6. Saito, K. et al. Cell 136, 891–902 (2009).

    Article  CAS  Google Scholar 

  7. Wilson, D. G. et al. J. Cell Biol. 193, 935–951 (2011).

    Google Scholar 

  8. De Matteis, M. A. & Luini, A. N. Engl. J. Med. 365, 927–938 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David J. Stephens.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stephens, D. Collagen secretion explained. Nature 482, 474–475 (2012). https://doi.org/10.1038/482474a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/482474a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing